Biology:YchF-GTPase C terminal protein domain
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Short description: Protein domain
| C terminal domain of YchF-GTPase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 ychf protein (hi0393) | |||||||||
| Identifiers | |||||||||
| Symbol | YchF-GTPase_C | ||||||||
| Pfam | PF06071 | ||||||||
| Pfam clan | CL0072 | ||||||||
| InterPro | IPR013029 | ||||||||
| SCOP2 | 1ni3 / SCOPe / SUPFAM | ||||||||
| CDD | cd04867 | ||||||||
| |||||||||
In molecular biology, this protein domain is found at the C terminus of the GTP-binding protein, YchF-GTPase found in both prokaryotes and eukaryotes.
Function
The function of this protein domain remains unknown, however, it is putatively thought to be necessary for ribosome function or for signal transduction from the ribosome to downstream targets. Additionally, GTPases are often described as a molecular switch.[1]
Structure
The crystal structure of Haemophilus influenzae has been determined.[2] This protein consists of three domains, of which the C-terminal domain which is composed of a six-stranded half-barrel curved around an alpha helix.
References
- ↑ "Evolution of a molecular switch: universal bacterial GTPases regulate ribosome function.". Mol Microbiol 41 (2): 289–97. 2001. doi:10.1046/j.1365-2958.2001.02536.x. PMID 11489118.
- ↑ "Crystal structure of the YchF protein reveals binding sites for GTP and nucleic acid". J. Bacteriol. 185 (14): 4031–7. July 2003. doi:10.1128/jb.185.14.4031-4037.2003. PMID 12837776.
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