Biology:ZAK

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Sterile alpha motif and leucine zipper containing kinase AZK, also known as ZAK, is a human gene.

This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Interactions

ZAK has been shown to interact with ZNF33A.

References

• Lee, Jin-Sun (28 February 2018). "Antitumorigenic Effects of ZAKβ, an Alternative Splicing Isoform of ZAK". The Chinese Journal of Physiology 61 (1): 25–34. doi:10.4077/CJP.2018.BAG528. PMID 29374956. 

Further reading

• "Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif.". Biochem. Biophys. Res. Commun. 274 (3): 811–6. 2000. doi:10.1006/bbrc.2000.3236. PMID 10924358. 
• "Identification and characterization of a novel MAP kinase kinase kinase, MLTK.". J. Biol. Chem. 276 (6): 4276–86. 2001. doi:10.1074/jbc.M008595200. PMID 11042189. 
• "Tissue distribution and functional expression of a cDNA encoding a novel mixed lineage kinase.". J. Mol. Cell. Cardiol. 33 (9): 1739–50. 2002. doi:10.1006/jmcc.2001.1437. PMID 11549352. 
• "MRK, a mixed lineage kinase-related molecule that plays a role in gamma-radiation-induced cell cycle arrest.". J. Biol. Chem. 277 (16): 13873–82. 2002. doi:10.1074/jbc.M111994200. PMID 11836244. 
• Yang JJ (2002). "Mixed lineage kinase ZAK utilizing MKK7 and not MKK4 to activate the c-Jun N-terminal kinase and playing a role in the cell arrest.". Biochem. Biophys. Res. Commun. 297 (1): 105–10. doi:10.1016/S0006-291X(02)02123-X. PMID 12220515. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• Yang JJ (2003). "A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle.". Biochem. Biophys. Res. Commun. 301 (1): 71–7. doi:10.1016/S0006-291X(02)02980-7. PMID 12535642. 
• "Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN.". J. Biochem. 133 (2): 181–7. 2004. doi:10.1093/jb/mvg022. PMID 12761180. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "A novel role for mixed-lineage kinase-like mitogen-activated protein triple kinase alpha in neoplastic cell transformation and tumor development.". Cancer Res. 64 (11): 3855–64. 2004. doi:10.1158/0008-5472.CAN-04-0201. PMID 15172994. 
• "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. 2004. doi:10.1016/j.cub.2004.07.051. PMID 15324660. 
• "The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway.". J. Biol. Chem. 279 (46): 47652–60. 2005. doi:10.1074/jbc.M409961200. PMID 15342622. 
• "Transforming growth factor-beta induces the expression of ANF and hypertrophic growth in cultured cardiomyoblast cells through ZAK.". Biochem. Biophys. Res. Commun. 324 (1): 424–31. 2004. doi:10.1016/j.bbrc.2004.09.067. PMID 15465036. 
• "ZAK re-programs atrial natriuretic factor expression and induces hypertrophic growth in H9c2 cardiomyoblast cells.". Biochem. Biophys. Res. Commun. 324 (3): 973–80. 2004. doi:10.1016/j.bbrc.2004.09.156. PMID 15485649. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha.". J. Biol. Chem. 280 (14): 13545–53. 2005. doi:10.1074/jbc.M410521200. PMID 15684425. 
• "Complete inhibition of anisomycin and UV radiation but not cytokine induced JNK and p38 activation by an aryl-substituted dihydropyrrolopyrazole quinoline and mixed lineage kinase 7 small interfering RNA.". J. Biol. Chem. 280 (19): 19298–305. 2005. doi:10.1074/jbc.M413059200. PMID 15737997. 
• "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.". Mol. Cell. Proteomics 4 (6): 785–95. 2005. doi:10.1074/mcp.M500021-MCP200. PMID 15778465. 
• "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. 2005. doi:10.1038/nature03466. PMID 15815621. Bibcode: 2005Natur.434..724H. 
• "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.