Biology:ZAK
From HandWiki
Sterile alpha motif and leucine zipper containing kinase AZK, also known as ZAK, is a human gene.[1]
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[1] [2]
Interactions
ZAK has been shown to interact with ZNF33A.[3]
References
- ↑ 1.0 1.1 "Entrez Gene: ZAK sterile alpha motif and leucine zipper containing kinase AZK". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=51776.
- ↑ "Cloning and Expression of ZAK, a Mixed Lineage Kinase-like Protein Containing a Leucine-Zipper and a Sterile-Alpha Motif". Biochemical and Biophysical Research Communications 274 (3): 811–816. 11 August 2000. doi:10.1006/bbrc.2000.3236. PMID 10924358. Bibcode: 2000BBRC..274..811L.
- ↑ "A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle". Biochemical and Biophysical Research Communications 301 (1): 71–77. Jan 2003. doi:10.1016/S0006-291X(02)02980-7. ISSN 0006-291X. PMID 12535642. Bibcode: 2003BBRC..301...71Y.
Further reading
- "Antitumorigenic Effects of ZAKβ, an Alternative Splicing Isoform of ZAK". The Chinese Journal of Physiology 61 (1): 25–34. 28 February 2018. doi:10.4077/CJP.2018.BAG528. PMID 29374956.
- "Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif.". Biochemical and Biophysical Research Communications 274 (3): 811–816. 2000. doi:10.1006/bbrc.2000.3236. PMID 10924358. Bibcode: 2000BBRC..274..811L.
- "Identification and characterization of a novel MAP kinase kinase kinase, MLTK.". Journal of Biological Chemistry 276 (6): 4276–4286. 2001. doi:10.1074/jbc.M008595200. PMID 11042189.
- "Tissue distribution and functional expression of a cDNA encoding a novel mixed lineage kinase.". Journal of Molecular and Cellular Cardiology 33 (9): 1739–1750. 2002. doi:10.1006/jmcc.2001.1437. PMID 11549352.
- "MRK, a mixed lineage kinase-related molecule that plays a role in gamma-radiation-induced cell cycle arrest.". Journal of Biological Chemistry 277 (16): 13873–13882. 2002. doi:10.1074/jbc.M111994200. PMID 11836244.
- "Mixed lineage kinase ZAK utilizing MKK7 and not MKK4 to activate the c-Jun N-terminal kinase and playing a role in the cell arrest.". Biochemical and Biophysical Research Communications 297 (1): 105–110. 2002. doi:10.1016/S0006-291X(02)02123-X. PMID 12220515. Bibcode: 2002BBRC..297..105Y.
- "A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle.". Biochemical and Biophysical Research Communications 301 (1): 71–77. 2003. doi:10.1016/S0006-291X(02)02980-7. PMID 12535642. Bibcode: 2003BBRC..301...71Y.
- "Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN.". Journal of Biochemistry 133 (2): 181–187. 2004. doi:10.1093/jb/mvg022. PMID 12761180.
- "A novel role for mixed-lineage kinase-like mitogen-activated protein triple kinase alpha in neoplastic cell transformation and tumor development.". Cancer Research 64 (11): 3855–3864. 2004. doi:10.1158/0008-5472.CAN-04-0201. PMID 15172994.
- "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Current Biology 14 (16): 1436–1450. 2004. doi:10.1016/j.cub.2004.07.051. PMID 15324660. Bibcode: 2004CBio...14.1436J.
- "The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway.". Journal of Biological Chemistry 279 (46): 47652–47660. 2005. doi:10.1074/jbc.M409961200. PMID 15342622.
- "Transforming growth factor-beta induces the expression of ANF and hypertrophic growth in cultured cardiomyoblast cells through ZAK.". Biochemical and Biophysical Research Communications 324 (1): 424–431. 2004. doi:10.1016/j.bbrc.2004.09.067. PMID 15465036. Bibcode: 2004BBRC..324..424H.
- "ZAK re-programs atrial natriuretic factor expression and induces hypertrophic growth in H9c2 cardiomyoblast cells.". Biochemical and Biophysical Research Communications 324 (3): 973–980. 2004. doi:10.1016/j.bbrc.2004.09.156. PMID 15485649. Bibcode: 2004BBRC..324..973H.
- "Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha.". Journal of Biological Chemistry 280 (14): 13545–13553. 2005. doi:10.1074/jbc.M410521200. PMID 15684425.
- "Complete inhibition of anisomycin and UV radiation but not cytokine induced JNK and p38 activation by an aryl-substituted dihydropyrrolopyrazole quinoline and mixed lineage kinase 7 small interfering RNA.". Journal of Biological Chemistry 280 (19): 19298–19305. 2005. doi:10.1074/jbc.M413059200. PMID 15737997.
- "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.". Molecular & Cellular Proteomics 4 (6): 785–795. 2005. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–1178. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
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