Biology:Zinc finger protein 280b

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Short description: Protein found in humans


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Zinc finger protein 280B is a protein that in humans is encoded by the ZNF280B gene.[1]

Function

The protein encoded by this gene is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. This gene is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for this gene, but only one of them is protein-coding.

References

This article incorporates text from the United States National Library of Medicine, which is in the public domain.