Biology:Zinc finger protein 444
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Zinc finger protein 444 is a protein that in humans is encoded by the ZNF444 gene.
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Function
This gene encodes a zinc finger protein which activates transcription of a scavenger receptor gene involved in the degradation of acetylated low-density lipoprotein (Ac-LDL) ("Characterization of the human gene encoding the scavenger receptor expressed by endothelial cell and its regulation by a novel transcription factor, endothelial zinc finger protein-2". J Biol Chem 277 (27): 24014–21. 2002. doi:10.1074/jbc.M201854200. PMID 11978792.). This gene is located in a cluster of zinc finger genes on chromosome 19 at q13.4. A pseudogene of this gene is located on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene.
References
Further reading
- "Characterization of the human gene encoding the scavenger receptor expressed by endothelial cell and its regulation by a novel transcription factor, endothelial zinc finger protein-2". J. Biol. Chem. 277 (27): 24014–21. 2002. doi:10.1074/jbc.M201854200. PMID 11978792.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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