Biology:Zinc uptake regulator
From HandWiki
Short description: Bacterial gene
| Zinc uptake regulation protein | |||||||
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| Symbol | Zur | ||||||
| PDB | 4MTD (ECOD) | ||||||
| UniProt | P0AC51 | ||||||
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The zinc uptake regulator (Zur) gene is a bacterial gene that codes for a transcription factor protein involved in zinc homeostasis. The protein is a member of the ferric uptake regulator family and binds zinc with high affinity. It typically functions as a repressor of zinc uptake proteins via binding to characteristic promoter DNA sequences in a dimer-of-dimers arrangement that creates strong cooperativity.[1] Under conditions of zinc deficiency, the protein undergoes a conformational change that prevents DNA binding, thereby lifting the repression and causing zinc uptake genes such as ZinT and the ZnuABC zinc transporter to be expressed.[1][2][3]
References
- ↑ 1.0 1.1 "Structural and mechanistic basis of zinc regulation across the E. coli Zur regulon". PLOS Biology 12 (11): e1001987. November 2014. doi:10.1371/journal.pbio.1001987. PMID 25369000.
- ↑ "Advances in the molecular understanding of biological zinc transport". Chemical Communications 51 (22): 4544–63. March 2015. doi:10.1039/c4cc10174j. PMID 25627157. http://wrap.warwick.ac.uk/76059/1/WRAP_Blindauer_C4CC10174J.pdf.
- ↑ "Severe zinc depletion of Escherichia coli: roles for high affinity zinc binding by ZinT, zinc transport and zinc-independent proteins". The Journal of Biological Chemistry 284 (27): 18377–89. July 2009. doi:10.1074/jbc.m109.001503. PMID 19377097.
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