Chemistry:3-Bromobenzaldehyde
3-Bromobenzaldehyde is an isomer of bromobenzaldehyde. It is a colorless viscous liquid.
Synthesis
3-Bromobenzaldehyde can be prepared from 3-nitrobenzaldehyde.[1]
To 1,2-dichloroethane (1,2-dichloroethane: 143.8 g, 1-bromo-2-chloroethane: 60.5 g, 1,2-dibromoethane: 4.8 g) recovered from Example 2 was added fresh 1,2-dichloroethane (41.5 g), and 98% aluminum chloride (0.65 mol, 88.6 g) was mixed. Into this was blown chlorine (0.25 mol, 17.8 g) at °C., and 97% benzaldehyde (0.50 mol, 54.6 g) was added over 1 hour at 40 °C. After bromine (0.30 mol, 48.0 g) was added dropwise to this mixture over 2 hours at 40 °C., the resulting mixtures were stirred for 2 hours at that temperature. The post-treatment was carried out by the similar procedure to that in Example 1. As a result, 83.1 g of 3-bromobenzaldehyde were obtained.[2]
Application
SNDRI Application patent (PC9839278):[5][6]
See also
References
- ↑ Johannes S. Buck and Walter S. Ide (1933). "m-Chlorobenzaldehyde". Organic Syntheses 13: 28. doi:10.15227/orgsyn.013.0028.
- ↑ https://prepchem.com/3-bromobenzaldehyde/
- ↑ Roger A. Sheldon, et al. U.S. Patent 4,036,887 (1977 to Shell USA Inc).
- ↑ Shinichi Matsuura & Osamu Miyano, U.S. Patent 4,945,186 (1990 to Toso Organic Chemical Co Ltd).
- ↑ James P. Beck, Mark A. Smith, Matt A. Curry, M. A. Aryl- and heteroarylsubstituted tetrahydroi-soquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin. WO2001032625 (2001 to Du Pont Pharmaceuticals Company).
- ↑ Bruce F Molino, Marlene Cohen, Barry Berkowitz, WO2006058016 (Amr Technology Inc).
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