Chemistry:4-CMTB
From HandWiki
4-CMTB is an experimental drug which acts as a potent and selective agonist for the free fatty acid receptor FFAR2 (GPR43). It has antiinflammatory effects and has been used to study the role of FFAR2 in immune system function and the potential application of FFAR2 agonists in the treatment of conditions such as dermatitis and asthma.[1][2][3][4][5][6][7]
References
- ↑ "Pharmacological properties of acid N-thiazolylamide FFA2 agonists". Pharmacology Research & Perspectives 3 (3). June 2015. doi:10.1002/prp2.141. PMID 26236484.
- ↑ "A Molecular Mechanism for Sequential Activation of a G Protein-Coupled Receptor". Cell Chemical Biology 23 (3): 392–403. March 2016. doi:10.1016/j.chembiol.2016.02.014. PMID 26991104.
- ↑ "The G Protein-Coupled Receptor FFAR2 Promotes Internalization during Influenza A Virus Entry". Journal of Virology 94 (2). January 2020. doi:10.1128/JVI.01707-19. PMID 31694949.
- ↑ "FFA2 Activation Ameliorates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in Mice". Biomolecules & Therapeutics 28 (3): 267–271. May 2020. doi:10.4062/biomolther.2019.160. PMID 32279475.
- ↑ "4-CMTB Ameliorates Ovalbumin-Induced Allergic Asthma through FFA2 Activation in Mice". Biomolecules & Therapeutics 29 (4): 427–433. July 2021. doi:10.4062/biomolther.2020.176. PMID 33875623.
- ↑ "Synthetic free fatty acid receptor (FFAR) 2 agonist 4-CMTB and FFAR4 agonist GSK13764 inhibit colon cancer cell growth and migration and regulate FFARs expression in in vitro and in vivo models of colorectal cancer". Pharmacological Reports 76 (6): 1403–1414. December 2024. doi:10.1007/s43440-024-00667-5. PMID 39432182.
- ↑ "Structural insights into lipid chain-length selectivity and allosteric regulation of FFA2". Nature Communications 16 (1). March 2025. doi:10.1038/s41467-025-57983-4. PMID 40140663. Bibcode: 2025NatCo..16.2809K.
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