Chemistry:5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole

5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole
Names
	IUPAC name 5,6-Dichloro-1-(β-D-ribofuranosyl)-1H-1,3-benzimidazole
	Systematic IUPAC name (2R,3R,4S,5R)-2-(5,6-Dichloro-1H-1,3-benzimidazol-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol
	Other names DRB, Dichlororibofuranosylbenzimidazole
Identifiers
CAS Number	53-85-0 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL375530 ;
ChemSpider	5683 ;
DrugBank	DB08473 ;
IUPHAR/BPS	5178;
PubChem CID	5894;
UNII	8153319T3Q;
	InChI InChI=1S/C12H12Cl2N2O4/c13-5-1-7-8(2-6(5)14)16(4-15-7)12-11(19)10(18)9(3-17)20-12/h1-2,4,9-12,17-19H,3H2/t9-,10-,11-,12-/m1/s1 Key: XHSQDZXAVJRBMX-DDHJBXDOSA-N ; InChI=1/C12H12Cl2N2O4/c13-5-1-7-8(2-6(5)14)16(4-15-7)12-11(19)10(18)9(3-17)20-12/h1-2,4,9-12,17-19H,3H2/t9-,10-,11-,12-/m1/s1 Key: XHSQDZXAVJRBMX-DDHJBXDOBF;
	SMILES Clc2cc1ncn(c1cc2Cl)[C@@H]3O[C@@H]([C@@H](O)[C@H]3O)CO;
Properties
Chemical formula	C12H12Cl2N2O4
Molar mass	319.14 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) is a chemical compound that inhibits transcription elongation by RNA Polymerase II. Sensitivity to DRB is dependent on DRB sensitivity inducing factor (DSIF), negative elongation factor (NELF), and positive transcription elongation factor b (P-TEFb). DRB is a nucleoside analog and also inhibits some protein kinases.^[1]

References

↑ Yamaguchi, Y.; Takagi, T.; Wada, T.; Yano, K.; Furuya, A.; Sugimoto, S.; Hasegawa, J.; Handa, H. (1999). "NELF, a Multisubunit Complex Containing RD, Cooperates with DSIF to Repress RNA Polymerase II Elongation.". Cell 97 (1): 41–51. doi:10.1016/S0092-8674(00)80713-8. PMID 10199401.

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