Chemistry:5-Formyluracil
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| Preferred IUPAC name
2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde | |
| Identifiers | |
3D model (JSmol)
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PubChem CID
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| Properties | |
| C5H4N2O3 | |
| Molar mass | 140.098 g·mol−1 |
| Hazards | |
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| GHS Signal word | Warning |
| H315, H319, H335 | |
| P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362, P403+233, P405, P501 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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Tracking categories (test):
5-Formyluracil is a heterocyclic organic base. It is produced from the oxidation of the methyl group of thymine. It is found in bacteriophages, prokaryotes, as well as mammalian cells. Being mutagenic, it is of particular interest in the field of epigenetics.[1] It has been implicated in the formation of cancer causing cells.[2]
References
- ↑ Klungland, A; Paulsen, R; Rolseth, V; Yamada, Y; Ueno, Y; Wiik, P; Matsuda, A; Seeberg, E et al. (2001). "5-Formyluracil and its nucleoside derivatives confer toxicity and mutagenicity to mammalian cells by interfering with normal RNA and DNA metabolism". Toxicol Lett 119 (1): 71–8. doi:10.1016/s0378-4274(00)00308-8. PMID 11275423.
- ↑ Wang, Yafen; Zhang, Xiong; Zou, Guangrong; Peng, Shuang; Liu, Chaoxing; Zhou, Xiang (2019-04-16). "Detection and Application of 5-Formylcytosine and 5-Formyluracil in DNA". Accounts of Chemical Research 52 (4): 1016–1024. doi:10.1021/acs.accounts.8b00543. ISSN 0001-4842. PMID 30666870. https://doi.org/10.1021/acs.accounts.8b00543.
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