Chemistry:ABS-201

From HandWiki

ABS-201 is an AI-designed monoclonal antibody against the prolactin receptor (PRLR) currently in Phase 1/2a clinical trial[1][2][3] for the treatment of androgenic alopecia (pattern hair loss) and endometriosis.[4][5][6][7] It is taken by subcutaneous injection.[4][6] ABS-201 is a possible first-in-class drug with a novel mechanism of action in the potential treatment of hair loss.[8] ABS-201 is under development by Absci.[9][10]

It is believed that ABS-201 works by activating dormant hair follicles and causing them to move from the telogen phase to the anagen phase.[6][7] In human ex vivo scalp model studies, ABS-201 stimulated hair regrowth, prolonged anagen phase, blocked catagen phase, inhibited telogen effluvium, and blocked hair from losing color.[11][12] ABS-201 has been found to produce robust hair regrowth as compared with minoxidil in mice and balding macaques.[6][7]

The clinical trial for ABS-201 is being overseen by prominent hair loss researcher Rodney Sinclair,[6] one of the principal investigators in minoxidil clinical trials.[13][14] The chemical structure of the drug does not yet appear to have been disclosed.[4]

See also

References

  1. ↑ Absci Pty Ltd. (2025-12-30). A Randomized, Double-Blind, Placebo-Controlled, Phase 1 First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Ascending Doses of ABS-201 in Healthy Adult Participants With and Without Androgenetic Alopecia (Report). clinicaltrials.gov. https://clinicaltrials.gov/study/NCT07317544. 
  2. ↑ "ABS 201 - Absci - AdisInsight". https://adisinsight.springer.com/drugs/800081953?error=cookies_not_supported&code=4f6f5165-4965-4693-8bc9-d401da2c2a5e. 
  3. ↑ "Absci Initiates First-in-Human Trial of AI-Designed Antibody ABS-201 for Hair Loss Treatment" (in en). 2025-12-04. https://trial.medpath.com/news/54c801e3e10e0288/absci-initiates-first-in-human-trial-of-ai-designed-antibody-abs-201-for-hair-loss-treatment. 
  4. ↑ 4.0 4.1 4.2 "ABS 201". 7 October 2025. https://adisinsight.springer.com/drugs/800081953. 
  5. ↑ "Delving into the Latest Updates on ABS-201(Absci Corp) with Synapse". 25 October 2025. https://synapse.patsnap.com/drug/df9036a4c8a543caa043bb22ec744267. 
  6. ↑ 6.0 6.1 6.2 6.3 6.4 "A New Hair Loss Drug Could Cure Balding and Reverse Graying". 20 October 2025. https://www.popularmechanics.com/science/health/a69077094/new-hair-regrowth-treatment/. 
  7. ↑ 7.0 7.1 7.2 "Absci 2024 R&D Day Presentation". Absci Corporation. 2024. https://investors.absci.com/static-files/5edb526c-2e03-4615-b4e4-494778d12441. 
  8. ↑ "Absci Initiates First-in-Human Trial of AI-Designed Antibody ABS-201 for Hair Loss Treatment" (in en). 2025-12-04. https://trial.medpath.com/news/54c801e3e10e0288/absci-initiates-first-in-human-trial-of-ai-designed-antibody-abs-201-for-hair-loss-treatment. 
  9. ↑ "ABS 201 - Absci - AdisInsight". https://adisinsight.springer.com/drugs/800081953?error=cookies_not_supported&code=dfbe1d5c-2318-44e2-ba70-e068fe0a2360. 
  10. ↑ "Delving into the Latest Updates on ABS-201(Absci Corp) with Synapse" (in en). https://synapse.patsnap.com/drug/df9036a4c8a543caa043bb22ec744267. 
  11. ↑ "ABS-201 KOL SEMINAR". December 12, 2025. https://investors.absci.com/events/event-details/abs-201-kol-seminar-anti-prlr-androgenetic-alopecia-program. 
  12. ↑ "ABS 201 - Absci - AdisInsight". https://adisinsight.springer.com/drugs/800081953?error=cookies_not_supported&code=a5bb5e27-e746-4f78-a5cf-858aa6148e21. 
  13. ↑ Applied Biology, Inc. (2018-10-04). Minoxidil Response Testing in Females With Female Pattern Hair Loss (Report). clinicaltrials.gov. https://clinicaltrials.gov/study/NCT02206802. 
  14. ↑ "A 32-week randomized, placebo-controlled, double-blinded pilot study to compare the efficacy and safety of low-dose oral minoxidil in male and female patients with patterned hair loss (androgenetic alopecia) followed by a 24-week open label extension period" (in en). 2021-11-15. https://trial.medpath.com/clinical-trial/25f9fb9c5cbfe0b8/actrn12618000606280-low-dose-oral-minoxidil-hair-loss. 

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