Chemistry:ABT-702

From HandWiki

ABT-702 is an experimental drug that acts as a selective inhibitor of the enzyme adenosine kinase. In animal studies it has analgesic and antiinflammatory effects, and has been useful in investigating the potential applications of adenosine kinase inhibitors in a number of medical applications.[1][2][3][4][5][6][7][8][9][10]

References

  1. ↑ "Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor". Journal of Medicinal Chemistry 44 (13): 2133–2138. June 2001. doi:10.1021/jm000314x. PMID 11405650. 
  2. ↑ "ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I. In vitro characterization and acute antinociceptive effects in the mouse". The Journal of Pharmacology and Experimental Therapeutics 295 (3): 1156–1164. December 2000. doi:10.1016/S0022-3565(24)39018-4. PMID 11082453. 
  3. ↑ "ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties. II. In vivo characterization in the rat". The Journal of Pharmacology and Experimental Therapeutics 295 (3): 1165–1174. December 2000. doi:10.1016/S0022-3565(24)39019-6. PMID 11082454. 
  4. ↑ "Adenosine kinase inhibition in the cochlea delays the onset of age-related hearing loss". Experimental Gerontology 46 (11): 905–914. November 2011. doi:10.1016/j.exger.2011.08.001. PMID 21846498. 
  5. ↑ "ABT-702, an adenosine kinase inhibitor, attenuates inflammation in diabetic retinopathy". Life Sciences 93 (2–3): 78–88. July 2013. doi:10.1016/j.lfs.2013.05.024. PMID 23770229. 
  6. ↑ "Inhibition of adenosine kinase attenuates inflammation and neurotoxicity in traumatic optic neuropathy". Journal of Neuroimmunology 277 (1–2): 96–104. December 2014. doi:10.1016/j.jneuroim.2014.10.006. PMID 25457840. 
  7. ↑ "An adenosine kinase inhibitor, ABT-702, inhibits spinal nociceptive transmission by adenosine release via equilibrative nucleoside transporters in rat". Neuropharmacology 97: 160–170. October 2015. doi:10.1016/j.neuropharm.2015.05.035. PMID 26066576. 
  8. ↑ "Adenosine kinase inhibition protects against cisplatin-induced nephrotoxicity". American Journal of Physiology. Renal Physiology 317 (1): F107–F115. July 2019. doi:10.1152/ajprenal.00385.2018. PMID 30995110. 
  9. ↑ "Inhibition of adenosine kinase attenuates myocardial ischaemia/reperfusion injury". Journal of Cellular and Molecular Medicine 25 (6): 2931–2943. March 2021. doi:10.1111/jcmm.16328. PMID 33523568. 
  10. ↑ "An adenosinergic positive feedback loop extends pharmacological cardioprotection duration". British Journal of Pharmacology 181 (23): 4920–4936. December 2024. doi:10.1111/bph.17331. PMID 39256947. 



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