Chemistry:ACT-335827
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ACT-335827 is an orally available, selective orexin 1 receptor antagonist with anxiolytic effects in animals. Unlike other orexin receptor antagonists, ACT-335827 lacks sedative effects and was found to have no impact on sleep architecture in mice.[1][2]
References
- ↑ "Discovery and characterization of ACT-335827, an orally available, brain penetrant orexin receptor type 1 selective antagonist". ChemMedChem 8 (6): 898–903. June 2013. doi:10.1002/cmdc.201300003. PMID 23589487.
- ↑ "Orexin 1 receptor antagonists in compulsive behavior and anxiety: possible therapeutic use". Frontiers in Neuroscience 8: 26. 2014. doi:10.3389/fnins.2014.00026. PMID 24592206.
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