Chemistry:AF-353

From HandWiki

AF-353 is a drug which acts as an antagonist of the P2X3 homotrimeric and P2X2/3 heterotrimeric forms of the P2X purinoreceptors. It has been found to block taste responses and has been proposed as an agent for masking the bitter taste of medications.[1][2][3]

See also

References

  1. ↑ "AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist". British Journal of Pharmacology 160 (6): 1387–1398. July 2010. doi:10.1111/j.1476-5381.2010.00796.x. PMID 20590629. 
  2. ↑ "Postsynaptic P2X3-containing receptors in gustatory nerve fibres mediate responses to all taste qualities in mice". The Journal of Physiology 593 (5): 1113–1125. March 2015. doi:10.1113/jphysiol.2014.281014. PMID 25524179. 
  3. ↑ "Topical application of a P2X2/P2X3 purine receptor inhibitor suppresses the bitter taste of medicines and other taste qualities". British Journal of Pharmacology 181 (17): 3282–3299. May 2024. doi:10.1111/bph.16411. PMID 38745397. 



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