Chemistry:AH-7614
From HandWiki
AH-7614 is an experimental drug which acts as a potent and selective antagonist for the free fatty acid receptor FFAR4 (GPR120), though it has also been described as an inverse agonist or negative allosteric modulator.[1][2] Agonists of FFAR4 have antiinflammatory effects and are of interest in the treatment of various conditions including diabetes and obesity, and as a selective FFAR4 antagonist AH-7614 is important for research into the function of this receptor.[3][4][5][6]
References
- ↑ "Probe-Dependent Negative Allosteric Modulators of the Long-Chain Free Fatty Acid Receptor FFA4". Molecular Pharmacology 91 (6): 630–641. June 2017. doi:10.1124/mol.116.107821. PMID 28385906.
- ↑ "Inverse agonism of the FFA4 free fatty acid receptor controls both adipogenesis and mature adipocyte function". Cellular Signalling 131. July 2025. doi:10.1016/j.cellsig.2025.111714. PMID 40057149.
- ↑ "The role of free-fatty acid receptor-4 (FFA4) in human cancers and cancer cell lines". Biochemical Pharmacology 150: 170–180. April 2018. doi:10.1016/j.bcp.2018.02.011. PMID 29452095.
- ↑ "Activation of Free Fatty Acid Receptor 4 Affects Intestinal Inflammation and Improves Colon Permeability in Mice". Nutrients 13 (8): 2716. August 2021. doi:10.3390/nu13082716. PMID 34444876.
- ↑ "Eicosapentaenoic Acid Rescues Cav1.2-L-Type Ca2+ Channel Decline Caused by Saturated Fatty Acids via Both Free Fatty Acid Receptor 4-Dependent and -Independent Pathways in Cardiomyocytes". International Journal of Molecular Sciences 25 (14): 7570. July 2024. doi:10.3390/ijms25147570. PMID 39062812.
- ↑ "Fish oil reduces intestinal fat absorption by promoting lacteal junction zippering via GPR120-VEGFR3-MLCK pathway". Journal of Advanced Research. May 2025. doi:10.1016/j.jare.2025.05.026. PMID 40412483.
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