Chemistry:AP8
From HandWiki
AP8 is an experimental drug which acts as a selective agonist for the free fatty acid receptor FFAR1 (GPR40). It has antiinflammatory and anti-fibrotic effects.[1][2][3]
References
- ↑ "Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40". Nature Structural & Molecular Biology 24 (7): 570–577. July 2017. doi:10.1038/nsmb.3417. PMID 28581512.
- ↑ "Addressing free fatty acid receptor 1 (FFAR1) activation using supervised molecular dynamics". Journal of Computer-aided Molecular Design 34 (11): 1181–1193. November 2020. doi:10.1007/s10822-020-00338-6. PMID 32851580. Bibcode: 2020JCAMD..34.1181A. https://pureportal.coventry.ac.uk/en/publications/addressing-free-fatty-acid-receptor-1-ffar1-activation-using-supervised-molecular-dynamics(5e4d5099-608c-4bcc-b90e-df440eb51dd0).html.
- ↑ "Insights into the molecular mechanism of positive cooperativity between partial agonist MK-8666 and full allosteric agonist AP8 of hGPR40 by Gaussian accelerated molecular dynamics (GaMD) simulations". Computational and Structural Biotechnology Journal 19: 3978–3989. 2021. doi:10.1016/j.csbj.2021.07.008. PMID 34377364.
 |  |
