Chemistry:Aditoprim

From HandWiki

Aditoprim is an antibacterial dihydrofolate reductase inhibitor.[1] It is currently being investigated for veterinary use, mostly in China for the treatment of various Streptococcus caused conditions.[2][3] A 2025 study found that it is toxic to the human gut microbiota as most antibiotics are, and established a microbiologically acceptable daily intake of 91.67 µg/kg.BW/day.[4]

References

  1. ↑ Then, RL; Keller, M (1988). "Properties of aditoprim, a new antibacterial dihydrofolate reductase inhibitor". Zentralblatt für Veterinärmedizin Reihe B 35 (2): 114–20. doi:10.1111/j.1439-0450.1988.tb00476.x. PMID 3420982. 
  2. ↑ Cheng, Guyue; Xu, Yamei; Zhu, Xudong; Xie, Shuyu; Wang, Liye; Huang, Lingli; Hao, Haihong; Liu, Zhenli et al. (2017-02-01). "The antibacterial activities of aditoprim and its efficacy in the treatment of swine streptococcosis" (in en). Scientific Reports 7 (1). doi:10.1038/srep41370. ISSN 2045-2322. PMID 28145487. PMC 5286432. https://www.nature.com/articles/srep41370. 
  3. ↑ Mi, Kun; Sun, Lei; Zhang, Lan; Tang, Aoran; Tian, Xiaoyuan; Hou, Yixuan; Sun, Lingling; Huang, Lingli (2024-04-17). "A physiologically based pharmacokinetic/pharmacodynamic model to determine dosage regimens and withdrawal intervals of aditoprim against Streptococcus suis" (in English). Frontiers in Pharmacology 15. ISSN 1663-9812. PMID 38694922. PMC 11061430. https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1378034/full. 
  4. ↑ Wang, Junhao; Liu, Chunbei; Gu, Fangtong; Gu, Yufeng; Hao, Haihong (2025-12-01). "Microbiological toxicology of the new antibiotic aditoprim on human intestinal microbiota". Toxicology Letters 414. doi:10.1016/j.toxlet.2025.111780. ISSN 0378-4274. https://www.sciencedirect.com/science/article/pii/S0378427425027262. 




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