Chemistry:Aficamten
From HandWiki
Short description: Chemical compound
 | |
| Clinical data | |
|---|---|
| Other names | CK-274 |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| ChEMBL | |
| Chemical and physical data | |
| Formula | C18H19N5O2 |
| Molar mass | 337.383 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
Aficamten (CK-274) is a cardiac myosin inhibitor[1] developed by Cytokinetics for the treatment of obstructive hypertrophic cardiomyopathy.[2][3][4]
References
- ↑ Chuang, Chihyuan; Collibee, Scott; Ashcraft, Luke; Wang, Wenyue; Vander Wal, Mark; Wang, Xiaolin; Hwee, Darren T.; Wu, Yangsong et al. (14 October 2021). "Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy" (in en). Journal of Medicinal Chemistry 64 (19): 14142–14152. doi:10.1021/acs.jmedchem.1c01290. ISSN 0022-2623. PMID 34606259. https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c01290.
- ↑ Zhao, Xue; Liu, Hongzhong; Tian, Wei; Fang, Ligang; Yu, Mengyang; Wu, Xiaofei; Liu, Aijing; Wan, Ruijie et al. (2023). "Safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple doses of aficamten in healthy Chinese participants: a randomized, double-blind, placebo-controlled, phase 1 study" (in en). Frontiers in Pharmacology 14. doi:10.3389/fphar.2023.1227470. PMID 37680714.
- ↑ Sebastian, Sneha Annie; Padda, Inderbir; Lehr, Eric J.; Johal, Gurpreet (September 2023). "Aficamten: A Breakthrough Therapy for Symptomatic Obstructive Hypertrophic Cardiomyopathy". American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions 23 (5): 519–532. doi:10.1007/s40256-023-00599-0. ISSN 1179-187X. PMID 37526885. https://pubmed.ncbi.nlm.nih.gov/37526885/.
- ↑ Maron, Martin S.; Masri, Ahmad; Choudhury, Lubna; Olivotto, Iacopo; Saberi, Sara; Wang, Andrew; Garcia-Pavia, Pablo; Lakdawala, Neal K. et al. (January 2023). "Phase 2 Study of Aficamten in Patients With Obstructive Hypertrophic Cardiomyopathy". Journal of the American College of Cardiology 81 (1): 34–45. doi:10.1016/j.jacc.2022.10.020. PMID 36599608.
 |  |
