Chemistry:Atractylodin
Atractylodin is a polyyne found in Atractylodes, in particular Atractylodes lancea and Atractylodes chinensis. It serves as the primary active component and the characteristic aromatic constituent in the volatile oil of the traditional Chinese medicine Cāng zhú, which is derived from the dried rhizomes of Atractylodes species.[1][2][3]
Atractylodin exhibits a range of pharmacological activities, including regulation of gastrointestinal motility, anti-inflammatory, antiviral, and antioxidant effects. These combined activities form the pharmacological basis for the traditional use of Cāng zhú, often as a key ingredient in formulations such as Po Chai Pills, to treat symptoms like abdominal bloating, loss of appetite, and diarrhea.[4][5][6][7]
References
- ↑ Bruns, K.; Dolhaine, H.; Weber, U. (1982). "Atractylodes lancea DC. (Compositae). Contribution on the Constituents of the Essential Oil". Aromatic Plants. Dordrecht: Springer Netherlands. pp. 207–210. doi:10.1007/978-94-009-7642-9_17. ISBN 978-94-009-7644-3. http://link.springer.com/10.1007/978-94-009-7642-9_17. Retrieved 2026-01-08.
- ↑ Bao, Shengchuan; Feng, Mei; Zhang, XiZhen; Xie, Mingjun; Teng, Jing (2025). "Multi-omics analysis reveals the mechanism of action of Atractylodin against depression". Journal of Natural Medicines 79 (5): 1067–1080. doi:10.1007/s11418-025-01930-6. ISSN 1340-3443. PMID 40613961. https://link.springer.com/10.1007/s11418-025-01930-6. Retrieved 2026-01-08.
- ↑ Sun, Zhejun; Zhang, Yuting; Peng, Xing; Huang, Shijie; Zhou, Huihao; Xu, Jun; Gu, Qiong (2022-04-22). "Diverse Sesquiterpenoids and Polyacetylenes from Atractylodes lancea and Their Anti-Osteoclastogenesis Activity". Journal of Natural Products 85 (4): 866–877. doi:10.1021/acs.jnatprod.1c00997. ISSN 0163-3864. PMID 35324175. Bibcode: 2022JNAtP..85..866S. https://pubs.acs.org/doi/10.1021/acs.jnatprod.1c00997. Retrieved 2026-01-08.
- ↑ Heo, Gwangbeom; Kim, Yuju; Kim, Eun-La; Park, Soyeong; Rhee, Sang Hoon; Jung, Jee H.; Im, Eunok (2023-01-02). "Atractylodin Ameliorates Colitis via PPARα Agonism". International Journal of Molecular Sciences 24 (1): 802. doi:10.3390/ijms24010802. ISSN 1422-0067. PMID 36614242.
- ↑ Xu, Lei; Zhou, Yonglin; Xu, Jingwen; Xu, Xiangzhu; Lu, Gejin; Lv, Qianghua; Wei, Lijuan; Deng, Xuming et al. (2022-10-28). "Anti-inflammatory, antioxidant and anti-virulence roles of atractylodin in attenuating Listeria monocytogenes infection". Frontiers in Immunology 13. doi:10.3389/fimmu.2022.977051. ISSN 1664-3224. PMID 36389842.
- ↑ Chae, Hee-Sung; Kim, Young-Mi; Chin, Young-Won (2016-09-02). "Atractylodin Inhibits Interleukin-6 by Blocking NPM-ALK Activation and MAPKs in HMC-1". Molecules 21 (9): 1169. doi:10.3390/molecules21091169. ISSN 1420-3049. PMID 27598116.
- ↑ Lyu, Zheng; Ji, Xufeng; Chen, Geng; An, Beiying (2019). "Atractylodin ameliorates lipopolysaccharide and d-galactosamine-induced acute liver failure via the suppression of inflammation and oxidative stress". International Immunopharmacology 72: 348–357. doi:10.1016/j.intimp.2019.04.005. PMID 31030090. https://linkinghub.elsevier.com/retrieve/pii/S1567576919300025. Retrieved 2026-01-08.
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