Chemistry:Aurodox
From HandWiki
Aurodox (X-5108, goldinomycin) is a naturally occurring polyketide antibiotic drug, first isolated in 1972 from Streptomyces goldiniensis. It is active against various species of Gram-positive bacteria through inhibition of the type III secretion system (T3SS), and while its chemical properties make it unsuitable for use in human medicine directly, it is used in antibiotic research and related compounds may be developed for medical use.[1][2][3]
See also
- Fluorothiazinone
References
- ↑ "Characterization of the Mode of Action of Aurodox, a Type III Secretion System Inhibitor from Streptomyces goldiniensis". Infection and Immunity 87 (2). February 2019. doi:10.1128/IAI.00595-18. PMID 30455200.
- ↑ "Insights into the structure-activity relationship of a type III secretion system inhibitor, aurodox". Bioorganic & Medicinal Chemistry Letters 69. August 2022. doi:10.1016/j.bmcl.2022.128779. PMID 35545199.
- ↑ "PurA is the main target of aurodox, a type III secretion system inhibitor". Proceedings of the National Academy of Sciences of the United States of America 121 (17). April 2024. doi:10.1073/pnas.2322363121. PMID 38640341. Bibcode: 2024PNAS..12122363W.
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