Chemistry:B7-33
From HandWiki
B7-33 is a synthetic 26-amino acid peptide with the sequence VIKLSGRELVRAQIAISGMSTWSKRSL or Val-Ile-Lys-Leu-Ser-Gly-Arg-Glu-Leu-Val-Arg-Ala-Gln-Ile-Ala-Ile-Ser-Gly-Met-Ser-Thr-Trp-Ser-Lys-Arg-Ser-Leu. It is an N-terminal truncated, C-terminal extended fragment from the B chain of human relaxin-2, and has similar anti-fibrotic effects to the full length peptide. It has been researched for conditions where excess fibrosis plays a role, such as cardiac fibrosis and pulmonary fibrosis.[1][2][3][4][5][6][7]
See also
- Cartalax
- Link-N
References
- ↑ "A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1". Chemical Science 7 (6): 3805–3819. June 2016. doi:10.1039/c5sc04754d. PMID 30155023.
- ↑ "Single chain peptide agonists of relaxin receptors". Molecular and Cellular Endocrinology 487: 34–39. May 2019. doi:10.1016/j.mce.2019.01.008. PMID 30641102.
- ↑ "B7-33, a Functionally Selective Relaxin Receptor 1 Agonist, Attenuates Myocardial Infarction-Related Adverse Cardiac Remodeling in Mice". Journal of the American Heart Association 9 (8). April 2020. doi:10.1161/JAHA.119.015748. PMID 32295457.
- ↑ "Analgesic effect of central relaxin receptor activation on persistent inflammatory pain in mice: behavioral and neurochemical data". Pain Reports 6 (2): e937. 2021. doi:10.1097/PR9.0000000000000937. PMID 34159282.
- ↑ "The single-chain relaxin mimetic, B7-33, maintains the cardioprotective effects of relaxin and more rapidly reduces left ventricular fibrosis compared to perindopril in an experimental model of cardiomyopathy". Biomedicine & Pharmacotherapy 160. April 2023. doi:10.1016/j.biopha.2023.114370. PMID 36753958.
- ↑ "A Lipidated Single-B-Chain Derivative of Relaxin Exhibits Improved In Vitro Serum Stability without Altering Activity". International Journal of Molecular Sciences 24 (7): 6616. April 2023. doi:10.3390/ijms24076616. PMID 37047588.
- ↑ "Further Developments towards a Minimal Potent Derivative of Human Relaxin-2". International Journal of Molecular Sciences 24 (16). August 2023. doi:10.3390/ijms241612670. PMID 37628851.
 |  |
