Chemistry:BIM-23027

From HandWiki

BIM-23027 is a cyclic hexapeptide which acts as a selective agonist at somatostatin receptor 2. It inhibits secretion of various hormones and increases dopamine release in brain tissue, however due to poor pharmacokinetic properties its use has mainly been restricted to basic research into the function of SSRT2 receptors and distinguishing their action from other somatostatin receptor subtypes.[1][2][3][4][5][6]

See also

References

  1. ↑ "Somatostatin receptors mediating inhibition of basal and stimulated electrogenic ion transport in rat isolated distal colonic mucosa". Naunyn-Schmiedeberg's Archives of Pharmacology 352 (4): 402–411. October 1995. doi:10.1007/BF00172777. PMID 8532068. 
  2. ↑ "Somatostatin-induced contraction of human isolated saphenous vein involves sst2 receptor-mediated activation of L-type calcium channels". Journal of Cardiovascular Pharmacology 26 (5): 721–728. November 1995. doi:10.1097/00005344-199511000-00008. PMID 8637186. 
  3. ↑ "Evidence that somatostatin sst2 receptors mediate striatal dopamine release". British Journal of Pharmacology 128 (6): 1346–1352. November 1999. doi:10.1038/sj.bjp.0702934. PMID 10578151. 
  4. ↑ "Somatostatin sst(2) receptor-mediated inhibition of mesenteric afferent nerves of the jejunum in the anesthetized rat". Gastroenterology 121 (2): 358–369. August 2001. doi:10.1053/gast.2001.26335. PMID 11487545. 
  5. ↑ "Drug design at peptide receptors: somatostatin receptor ligands". Journal of Molecular Neuroscience 18 (1–2): 15–27. 2002. doi:10.1385/JMN:18:1-2:15. PMID 11931345. 
  6. ↑ "Cellular actions of somatostatin on rat periaqueductal grey neurons in vitro". British Journal of Pharmacology 142 (8): 1273–1280. August 2004. doi:10.1038/sj.bjp.0705894. PMID 15265812. 



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