Chemistry:Bevurogant
From HandWiki
Bevurogant (BI 730357) is a drug which acts as a potent and selective antagonist (or perhaps inverse agonist) of the receptor RAR-related orphan receptor gamma (RORγ). It has anti-inflammatory effects and has been researched for the treatment of various conditions in which inflammation plays a role.[1][2]
References
- ↑ "The Effect of BI 730357 (Retinoic Acid-Related Orphan Receptor Gamma t Antagonist, Bevurogant) on the Pharmacokinetics of a Transporter Probe Cocktail, Including Digoxin, Furosemide, Metformin, and Rosuvastatin: An Open-Label, Non-randomized, 2-Period Fixed-Sequence Trial in Healthy Subjects". Clinical Pharmacology in Drug Development 13 (2): 197–207. February 2024. doi:10.1002/cpdd.1344. PMID 37960990.
- ↑ "Assessing Drug-Drug Interaction and Food Effect for BCS Class 2 Compound BI 730357 (Retinoic Acid-Related Orphan Receptor Gamma Antagonist, Bevurogant) Using a Physiology-Based Pharmacokinetics Modeling (PBPK) Approach with Semi-Mechanistic Absorption". Pharmaceutics 17 (3): 314. March 2025. doi:10.3390/pharmaceutics17030314. PMID 40142978.
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