Chemistry:Bromophene
Bromophene (MC21-A or C58) is a bactericidal antibiotic first isolated from the O-BC30 strain of a marine bacterium, Pseudoalteromonas phenolica.[1] A 2024 study reported that bromophene exhibited antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), with a minimum inhibitory concentration of 2 μg/mL against 39 different isolates. In the same study, bromophene exhibited in vitro antibacterial activity comparable to or greater than that of daptomycin, vancomycin, and linezolid under the conditions tested.[2] Additionally, bromophene eradicated established MRSA biofilms at a concentration of 8 μg/mL in vitro, whereas vancomycin did not achieve partial biofilm eradication at the concentrations evaluated in the same study.[2]
Mechanism of Action
The mechanism of action for bromophene has not been fully elucidated. However, previous reports describe increased bacterial membrane permeability without cell lysis.[1][2]
References
- ↑ 1.0 1.1 Isnansetyo, Alim; Kamei, Yuto (February 2003). "MC21-A, a Bactericidal Antibiotic Produced by a New Marine Bacterium, Pseudoalteromonas phenolica sp. nov. O-BC30T, against Methicillin-Resistant Staphylococcus aureus". Antimicrobial Agents and Chemotherapy (Washington, DC: American Society for Microbiology) 47 (2): 480–488. doi:10.1128/AAC.47.2.480-488.2003. ISSN 1098-6596. OCLC 678833406. PMID 12543647.
- ↑ 2.0 2.1 2.2 Shah KN, Shah PN, Agobe FO, Lovato K, Gao H, Ogun O, Hoffman C, Yabe-Gill M, Chen Q, Sweatt J, Chirra B, Muñoz-Medina R, Farmer DE, Kürti L, Cannon CL. 2024. Antimicrobial activity of a natural compound and analogs against multi-drug-resistant Gram-positive pathogens. Microbiology Spectrum 12:e01515-22. https://doi.org/10.1128/spectrum.01515-22
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