Chemistry:CATPB
From HandWiki
CATPB is an experimental drug which acts as a potent and selective antagonist for the free fatty acid receptor FFAR2 (GPR43), and is used for research into the function of this receptor.[1][2][3][4][5][6]
References
- ↑ "Selective novel inverse agonists for human GPR43 augment GLP-1 secretion". European Journal of Pharmacology 771: 1–9. January 2016. doi:10.1016/j.ejphar.2015.12.010. PMID 26683635.
- ↑ "Neutrophil priming that turns natural FFA2R agonists into potent activators of the superoxide generating NADPH-oxidase". Journal of Leukocyte Biology 104 (6): 1117–1132. December 2018. doi:10.1002/JLB.2A0318-130RR. PMID 30134499.
- ↑ "Structure-Activity Relationship Explorations and Discovery of a Potent Antagonist for the Free Fatty Acid Receptor 2". ChemMedChem 16 (21): 3326–3341. November 2021. doi:10.1002/cmdc.202100356. PMID 34288488. https://portal.findresearcher.sdu.dk/da/publications/5992990e-cf63-4481-a579-0dc9bca0b801.
- ↑ "Constitutively active GPR43 is crucial for proper leukocyte differentiation". FASEB Journal 37 (1): e22676. January 2023. doi:10.1096/fj.202201591R. PMID 36468834.
- ↑ "Discovery of Potent Tetrazole Free Fatty Acid Receptor 2 Antagonists". Journal of Medicinal Chemistry 66 (9): 6105–6121. May 2023. doi:10.1021/acs.jmedchem.2c01935. PMID 37129317.
- ↑ "Potential antitumor effects of short-chain fatty acids in breast cancer models". American Journal of Cancer Research 14 (5): 1999–2019. 2024. doi:10.62347/ETUQ6763. PMID 38859825.
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