Chemistry:CJC-1295

From HandWiki
Short description: Chemical compound
CJC-1295
Clinical data
Routes of
administration		Subcutaneous injection
ATC code
  • None
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC152H252N44O42
Molar mass3367.954 g·mol−1
3D model (JSmol)

CJC-1295, also known as DAC:GRF (short for drug affinity complex:growth hormone-releasing factor), is a synthetic analogue of growth hormone-releasing hormone (GHRH) (also known as growth hormone-releasing factor (GRF)) and a growth hormone secretagogue (GHS) which was developed by ConjuChem Biotechnologies.[1][2][3] It is a modified form of GHRH (1-29) with improved pharmacokinetics, especially in regard to half-life.[1][2][3][4]

Effects

CJC-1295 markedly increases plasma growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels in both animals and humans.[1][2][3][5] With a single injection, in human subjects, CJC-1295 increases plasma GH levels by 2- to 10-fold for 6 days or longer and plasma IGF-1 levels by 0.5- to 3-fold for 9 to 11 days.[3] The drug has an estimated half-life of about 6 to 8 days in humans.[3] With multiple doses of CJC-1295, IGF-1 levels were found to remain elevated in humans for up to 28 days.[3]

CJC-1295 has been shown to extend the half-life and bioavailability of growth-hormone-releasing hormone 1-29 and stimulate insulin-like growth factor 1 secretion. It increases the half-life of acting agents by bioconjugation.[6]

Risks

CJC-1295 was under investigation for the treatment of lipodystrophy and growth hormone deficiency and reached phase II clinical trials but was discontinued upon the death of one of the trial subjects.[7][8] The attending physician of the trial believed that the most likely explanation for the incident was that the patient had asymptomatic coronary artery disease with plaque rupture and occlusion, and that the occurrence was unrelated to treatment with CJC-1295.[8] Research was terminated nonetheless as a precaution.[8] CJC-1295 has found grey market use for bodybuilding purposes, with this, in some countries such as the Netherlands, being an illicit use.[7][9]

See also

  • List of growth hormone secretagogues

References

  1. ↑ 1.0 1.1 1.2 "Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog". Endocrinology 146 (7): 3052–8. July 2005. doi:10.1210/en.2004-1286. PMID 15817669. https://www.researchgate.net/publication/228484039. 
  2. ↑ 2.0 2.1 2.2 "Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse". American Journal of Physiology. Endocrinology and Metabolism 291 (6): E1290-4. December 2006. doi:10.1152/ajpendo.00201.2006. PMID 16822960. 
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 "Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults". The Journal of Clinical Endocrinology and Metabolism 91 (3): 799–805. March 2006. doi:10.1210/jc.2005-1536. PMID 16352683. https://zenodo.org/record/1083962. 
  4. ↑ "The discovery of growth hormone-releasing hormone: an update". Journal of Neuroendocrinology 20 (6): 653–4. June 2008. doi:10.1111/j.1365-2826.2008.01740.x. PMID 18601685. 
  5. ↑ "Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog". The Journal of Clinical Endocrinology and Metabolism 91 (12): 4792–7. December 2006. doi:10.1210/jc.2006-1702. PMID 17018654. 
  6. ↑ "Current Research Findings Regarding CJC-1295". Neo Scientific. 2 June 2015. http://neobiolab.com/research/current-research-findings-regarding-cjc-1295. "The reason why CJC1295 possesses the ability to lengthen the half-life within the active agent has to do with the scientific process known as bioconjugation. This technology, which is relatively new in nature, is defined by its ability to take a reactive group and bond it to a peptide (Aslam and Dent). This attachment causes a reaction with a nucleophilic unit; a typically partially molecule that is found within the bloodstream of an animal test subject. This reaction in turn causes a more stable bond to occur. This specific peptide has an especially high attraction to albumin, a globular protein that is soluble in water. This affinity prohibits natural degradation, which in turn increases the peptide’s half-life (Hermanson). Additionally, clinical research performed on animal test subjects has thus far shown that there have been no signs of DPP-IV degradation present when CJC-1295 was introduced (Gonzalez, US Peptide Articles)." 
  7. ↑ 7.0 7.1 "Identification of peptide and protein doping related drug compounds confiscated in Denmark between 2007-2013". Scandinavian Journal of Forensic Science 20 (2): 42–49. 2014. doi:10.2478/sjfs-2014-0003. ISSN 2353-0707. 
  8. ↑ 8.0 8.1 8.2 ConjuChem (August 2006). "Patient Died in Lipodystrophy Drug Study". http://www.natap.org/2006/newsUpdates/081106_02.htm. 
  9. ↑ "Identification of CJC-1295, a growth-hormone-releasing peptide, in an unknown pharmaceutical preparation". Drug Testing and Analysis 2 (11–12): 647–50. 2010. doi:10.1002/dta.233. PMID 21204297. 

External links



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