Chemistry:CMLD-2
From HandWiki
CMLD-2 is an experimental drug which acts as an inhibitor of the RNA-binding HuR protein. Elevated levels of HuR are found in many forms of cancer, and CMLD-2 is being researched for potential applications in cancer treatment.[1][2][3][4] It also has anti-inflammatory effects, and may also be useful for the treatment of neuropathic pain,[5][6] as well as asthma,[7] and Hepatitis B.[8]
See also
- KH-3
- SRI-42127
References
- ↑ "HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells". Scientific Reports 7 (1). August 2017. doi:10.1038/s41598-017-07787-4. PMID 28855578. Bibcode: 2017NatSR...7.9694M.
- ↑ "The HuR CMLD-2 inhibitor exhibits antitumor effects via MAD2 downregulation in thyroid cancer cells". Scientific Reports 9 (1). May 2019. doi:10.1038/s41598-019-43894-0. PMID 31089242. Bibcode: 2019NatSR...9.7374A.
- ↑ "MUC16 promotes triple-negative breast cancer lung metastasis by modulating RNA-binding protein ELAVL1/HUR". Breast Cancer Research 25 (1). March 2023. doi:10.1186/s13058-023-01630-7. PMID 36918912.
- ↑ "Targeting the HuR/E2F7 axis synergizes with bortezomib against multiple myeloma". Acta Pharmacologica Sinica 46 (8): 2296–2309. March 2025. doi:10.1038/s41401-025-01529-3. PMID 40133626.
- ↑ "The RNA-Binding Protein HuR Is Integral to the Function of Nociceptors in Mice and Humans". The Journal of Neuroscience 42 (49): 9129–9141. December 2022. doi:10.1523/JNEUROSCI.1630-22.2022. PMID 36270801.
- ↑ "Electroacupuncture Relieves HuR/KLF9-Mediated Inflammation to Enhance Neurological Repair after Spinal Cord Injury". eNeuro 10 (11). November 2023. doi:10.1523/ENEURO.0190-23.2023. PMID 37940560.
- ↑ "HuR-Targeted Inhibition Impairs Th2 Proinflammatory Responses in Asthmatic CD4+ T Cells". Journal of Immunology 208 (1): 38–48. January 2022. doi:10.4049/jimmunol.2100635. PMID 34862257.
- ↑ "Hepatitis B virus RNAs co-opt ELAVL1 for stabilization and CRM1-dependent nuclear export". PLOS Pathogens 20 (2). February 2024. doi:10.1371/journal.ppat.1011999. PMID 38306394.
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