Chemistry:CPCCOEt
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Short description: Chemical compound
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| Formula | C13H13NO4 |
| Molar mass | 247.250 g·mol−1 |
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CPCCOEt is a drug used in scientific research, which acts as a non-competitive antagonist at the metabotropic glutamate receptor subtype mGluR1, with high selectivity although only moderate binding affinity.[1][2] It is used mainly in basic research into the function of the mGluR1 receptor,[3][4] including the study of behavioural effects in animals including effects on memory and addiction.[5][6]
See also
References
- ↑ "CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding". Molecular Pharmacology 55 (3): 453–61. March 1999. PMID 10051528.
- ↑ "Chiral resolution, pharmacological characterization, and receptor docking of the noncompetitive mGlu1 receptor antagonist (+/-)-2-hydroxyimino- 1a, 2-dihydro-1H-7-oxacyclopropa[b]naphthalene-7a-carboxylic acid ethyl ester". Journal of Medicinal Chemistry 43 (23): 4428–36. November 2000. doi:10.1021/jm0009944. PMID 11087567.
- ↑ "The mGlu1 antagonist CPCCOEt enhances the climbing fibre response in Purkinje neurones independently of glutamate receptors". Neuropharmacology 52 (2): 450–8. February 2007. doi:10.1016/j.neuropharm.2006.08.014. PMID 17045308.
- ↑ "mGluR1-mediated facilitation of long-term potentiation at inhibitory synapses on a cerebellar Purkinje neuron". The European Journal of Neuroscience 27 (4): 884–96. February 2008. doi:10.1111/j.1460-9568.2008.06063.x. PMID 18279362.
- ↑ "Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: potential insight into their anti-addictive properties". Drug and Alcohol Dependence 85 (2): 142–56. November 2006. doi:10.1016/j.drugalcdep.2006.04.003. PMID 16697125.
- ↑ "Blockade of amygdala metabotropic glutamate receptor subtype 1 impairs fear extinction". Biochemical and Biophysical Research Communications 355 (1): 188–93. March 2007. doi:10.1016/j.bbrc.2007.01.125. PMID 17292864.
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