Chemistry:CYM50308
From HandWiki
CYM50308 (ML248) is a drug which acts as a selective agonist at the sphingosine-1-phosphate receptor S1PR4. It is used for research into the structure and function of the S1PR4 receptor, and has demonstrated potential applications for S1PR4 agonists in the treatment of asthma.[1][2][3]
References
- ↑ "Enhanced CXCR4 Expression of Human CD8Low T Lymphocytes is Driven by S1P4". Frontiers in Immunology 12. 2021. doi:10.3389/fimmu.2021.668884. PMID 34504486.
- ↑ "Sphingosine-1-Phosphate Receptor 4 Attenuates Neutrophilic Airway Inflammation in Experimental Asthma via Repressing Proinflammatory Macrophage Activation". International Journal of Biological Sciences 19 (5): 1597–1615. 2023. doi:10.7150/ijbs.80256. PMID 37056936.
- ↑ "S1P receptor modulators affect the toxicity of amyloid β oligomers in microglial and neuronal cells". Folia Neuropathologica 62 (4): 348–361. 2024. doi:10.5114/fn.2024.145758. PMID 39963030.
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