Chemistry:Cefilavancin

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Cefilavancin (TD-1792) is an experimental antibiotic medication developed for the treatment of bacterial infections such as drug-resistant strains of Staphylococcus aureus. It is a prodrug which is also a codrug, injected intravenously and then cleaved inside the body to two active components, one of which is a modified form of vancomycin and the other a cephalosporin antibiotic. In clinical trials cefilavancin has shown similar efficacy with reduced side effects compared to vancomycin itself.[1][2][3][4][5][6][7][8]

See also

  • Rifaquizinone

References

  1. ↑ "Exploring the positional attachment of glycopeptide/beta-lactam heterodimers". The Journal of Antibiotics 61 (10): 603–614. October 2008. doi:10.1038/ja.2008.80. PMID 19168974. 
  2. ↑ "In vitro activity of TD-1792, a multivalent glycopeptide-cephalosporin antibiotic, against 377 strains of anaerobic bacteria and 34 strains of Corynebacterium species". Antimicrobial Agents and Chemotherapy 56 (4): 2194–2197. April 2012. doi:10.1128/AAC.06274-11. PMID 22290981. 
  3. ↑ "TD-1792 versus vancomycin for treatment of complicated skin and skin structure infections". Antimicrobial Agents and Chemotherapy 56 (11): 5476–5483. November 2012. doi:10.1128/aac.00712-12. PMID 22869571. 
  4. ↑ "Staph wars: the antibiotic pipeline strikes back". Microbiology (Reading, England) 169 (9). September 2023. doi:10.1099/mic.0.001387. PMID 37656158. 
  5. ↑ "Macrocycle-Antibiotic Hybrids: A Path to Clinical Candidates". Frontiers in Chemistry 9. 2021. doi:10.3389/fchem.2021.659845. PMID 33996753. Bibcode: 2021FrCh....9..317S. 
  6. ↑ "Tackling the outer membrane: facilitating compound entry into Gram-negative bacterial pathogens". npj Antimicrobials and Resistance 1 (1). December 2023. doi:10.1038/s44259-023-00016-1. PMID 39843585. 
  7. ↑ "Bifunctional antibiotic hybrids: A review of clinical candidates". Frontiers in Pharmacology 14. 2023. doi:10.3389/fphar.2023.1158152. PMID 37397488. 
  8. ↑ "Strategic re-engineering of antibiotics". Nature Reviews Bioengineering 3 (3): 213–229. 2024. doi:10.1038/s44222-024-00250-w. PMID 40384761. 



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