Chemistry:Chloroethylnorapomorphine
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| Names | |
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| IUPAC name
12a-Chloro-12a-homo-6aβ-aporphine-10,11-diol
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| Systematic IUPAC name
(6aR)-6-(2-Chloroethyl)-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol | |
| Other names
(−)-N-(2-Chloroethyl)-norapomorphine
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| Identifiers | |
3D model (JSmol)
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| Properties | |
| C18H18ClNO2 | |
| Molar mass | 315.80 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify (what is   ?)
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Tracking categories (test):
Chloroethylnorapomorphine is a chemical once thought to be an irreversible dopamine D2 receptor antagonist;[1][2] however, it was later proved to be reversible.[3]
References
- ↑ Cohen, SA; Neumeyer, JL. (Oct 1983). "Kinetics of solvolysis of N-(2-chloroethyl)norapomorphine, an irreversible dopamine receptor antagonist". Journal of Medicinal Chemistry 26 (10): 1348–53. doi:10.1021/jm00364a003. PMID 6620296.
- ↑ Guan, JH; Neumeyer, JL; Filer, CN; Ahern, DG; Lilly, L; Watanabe, M; Grigoriadis, D; Seeman, P. (Jun 1984). "N-(2-chloroethyl) [8,9-2H]norapomorphine, an irreversible ligand for dopamine receptors: synthesis and application". Journal of Medicinal Chemistry 27 (6): 806–10. doi:10.1021/jm00372a019. PMID 6737423.
- ↑ Lehmann, J; Langer, SZ (1982). "Dopamine autoreceptors differ pharmacologically from postsynaptic dopamine receptors: Effects of (−)-N-(2-chloroethyl)-norapomorphine". European Journal of Pharmacology 77 (1): 85–6. doi:10.1016/0014-2999(82)90542-8. PMID 7060630.
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