Chemistry:Chlorohydroxyphenylglycine
From HandWiki
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| Names | |
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| IUPAC name
Amino(2-chloro-5-hydroxyphenyl)acetic acid
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| Identifiers | |
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3D model (JSmol)
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| Abbreviations | CHPG |
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PubChem CID
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| Properties | |
| C8H6ClNO3 | |
| Molar mass | 199.59 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Tracking categories (test):
2-Chloro-5-hydroxyphenylglycine or CHPG is an agonist of the metabotropic glutamate receptors, specific for mGluR5.[1]
It is capable of directly potentiating the depolarization of hippocampal CA1 neurons induced through NMDA administration.[2]
References
- ↑ Kammermeier, Paul J (2012). "The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency". BMC Pharmacology 12: 6. doi:10.1186/1471-2210-12-6. PMID 22642439.
- ↑ Collingridge G.; Volianskis A.; Bannister N.; France G.; Hanna L.; Mercier M.; Tidball P.; Fang G. et al. (2013). "The NMDA receptor as a target for cognitive enhancement". Neuropharmacology 64: 13–26. doi:10.1016/j.neuropharm.2012.06.051. PMID 22796429.
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