Chemistry:DFL23916
From HandWiki
DFL23916 is an experimental drug which acts as a mixed agonist for the free fatty acid receptors FFAR1 (GPR40) and FFAR4 (GPR120). Unlike the older drug GW9508 which is selective for FFAR1, DFL23916 has a balanced efficacy at both receptor targets. It increases GLP-1 secretion and improved glucose homeostasis in mice.[1][2]
References
- ↑ "A new synthetic dual agonist of GPR120/GPR40 induces GLP-1 secretion and improves glucose homeostasis in mice". Biomedicine & Pharmacotherapy 139. July 2021. doi:10.1016/j.biopha.2021.111613. PMID 33895521.
- ↑ "A novel free fatty acid receptor agonist improving metabolic health in Drosophila models". Pharmacological Research 216. June 2025. doi:10.1016/j.phrs.2025.107769. PMID 40348099.
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