Chemistry:Dibutyl squarate
From HandWiki
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| Names | |
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| IUPAC name
3,4-Dibutoxy-3-cyclobutene-1,2-dione
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| Other names
Squaric acid dibutyl ester; SADBE
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| Identifiers | |
3D model (JSmol)
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| 1968189 | |
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| DrugBank | |
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PubChem CID
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| Properties | |
| C12H18O4 | |
| Molar mass | 226.272 g·mol−1 |
| Hazards | |
| GHS pictograms | 
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| GHS Signal word | Warning |
| H315, H317, H319, H335 | |
| P261, P264, P264+265Script error: No such module "Preview warning".Category:GHS errors, P271, P272, P280, P302+352, P304+340, P305+351+338, P319Script error: No such module "Preview warning".Category:GHS errors, P321, P332+317Script error: No such module "Preview warning".Category:GHS errors, P333+313, P337+317Script error: No such module "Preview warning".Category:GHS errors, P362+364Script error: No such module "Preview warning".Category:GHS errors, P403+233, P405, P501 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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Tracking categories (test):
Dibutyl squarate (also known as squaric acid dibutyl ester or SADBE) is a chemical compound with the molecular formula C12H18O4. It is the dibutyl derivative of squaric acid.
Medically, it is used for the treatment of warts[1] and for treating alopecia areata or alopecia totalis (autoimmune hair loss) through topical immunotherapy involving the production of an allergic rash.[2][3] Dibutyl squarate is currently undergoing trials for use in treating herpes labialis (cold sores).[4]
References
- ↑ Silverberg, Nanette B.; Lim, Joseph K.; Paller, Amy S.; Mancini, Anthony J. (2000). "Squaric acid immunotherapy for warts in children". Journal of the American Academy of Dermatology 42 (5): 803–808. doi:10.1067/mjd.2000.103631. PMID 10775858.
- ↑ Yoshimasu, Takashi; Furukawa, Fukumi (2016). "Modified immunotherapy for alopecia areata". Autoimmunity Reviews 15 (7): 664–667. doi:10.1016/j.autrev.2016.02.021. PMID 26932732.
- ↑ Holzer, A. M.; Kaplan, L. L.; Levis, W. R. (2006). "Haptens as drugs: contact allergens are powerful topical immunomodulators". J. Drugs Dermatol. 5 (5): 410–416. PMID 16703776.
- ↑ Kimball, Alexandra (2017-05-05). A Clinical Trial to Test the Safety and Efficacy of Squaric Acid Dibutyl Ester for the Treatment of Herpes Labialis. Massachusetts General Hospital. https://clinicaltrials.gov/ct2/show/NCT01971385.
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