Chemistry:Emavusertib
From HandWiki
Emavusertib (CA-4948) is a drug which acts as a selective inhibitor of the enzyme Interleukin-1 receptor-associated kinase 4 (IRAK-4) and was developed for the treatment of some forms of cancer.[1][2][3]
See also
- Zabedosertib
- Zimlovisertib
References
- ↑ "Discovery of CA-4948, an Orally Bioavailable IRAK4 Inhibitor for Treatment of Hematologic Malignancies". ACS Medicinal Chemistry Letters 11 (12): 2374–2381. December 2020. doi:10.1021/acsmedchemlett.0c00255. PMID 33335659.
- ↑ "Oral IRAK-4 Inhibitor CA-4948 Is Blood-Brain Barrier Penetrant and Has Single-Agent Activity against CNS Lymphoma and Melanoma Brain Metastases". Clinical Cancer Research 29 (9): 1751–1762. May 2023. doi:10.1158/1078-0432.CCR-22-1682. PMID 36749885.
- ↑ "IRAK-4 inhibition: emavusertib for the treatment of lymphoid and myeloid malignancies". Frontiers in Immunology 14. 2023. doi:10.3389/fimmu.2023.1239082. PMID 37954584.
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