Chemistry:Erogorgiaene
From HandWiki
Erogorgiaene is a bicyclic compound found in marine octocoral Psuedoptergorgia elisabethae. It is used as an intermediate to synthesize pseudopterosin and is made by dehydrogenizing elisabethatriene so that a benzene ring is formed.[1]
Research
Erogorgiaene was found to have potential as a antibiotic against mycobacterium tuberculosis.[2] However, limited natural supply and expensive chemical synthesis keeps the usage of the antiboitic very low.[3]
References
- ↑ Kohl, Amber C.; Kerr, Russell G. (2003-11-26). "Pseudopterosin Biosynthesis: Aromatization of the Diterpene Cyclase Product, Elisabethatriene" (in en). Marine Drugs 1 (1): 54–65. doi:10.3390/md101054. ISSN 1660-3397.
- ↑ Incerti-Pradillos, Celia A.; Kabeshov, Mikhail A.; O'Hora, Paul S.; Shipilovskikh, Sergei A.; Rubtsov, Aleksandr E.; Drobkova, Vera A.; Balandina, Svetlana Yu.; Malkov, Andrei V. (2016). "Asymmetric Total Synthesis of (−)-Erogorgiaene and Its C-11 Epimer and Investigation of Their Antimycobacterial Activity" (in en). Chemistry – A European Journal 22 (40): 14390–14396. doi:10.1002/chem.201602440. ISSN 1521-3765. PMID 27529822. https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201602440.
- ↑ Munich, Technical University of. "Designed Bacteria Produce Coral Antibiotic" (in en). https://www.labmanager.com/designed-bacteria-produce-coral-antibiotic-23607.
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