Chemistry:Famoxadone
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| IUPAC name
(RS)-5-Methyl-5-(4-phenoxyphenyl)-3-(phenylamino)-1,3-oxazolidine-2,4-dione
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| Other names
Famoxate; FMX
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| Properties | |
| C22H18N2O4 | |
| Molar mass | 374.396 g·mol−1 |
| Melting point | 140.3-141.8 °C |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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| Infobox references | |
Famoxadone is a fungicide to protect agricultural products against various fungal diseases on fruiting vegetables, tomatoes, potatoes, curcurbits, lettuce and grapes.[1] It is used in combination with cymoxanil.[1][2] Famoxadone is a QoI, albeit with a chemistry different from most QoIs. (It is an oxazolidine-dione while most are strobilurins.)[3][4][5] It is commonly used against Plasmopara viticola,[3] Alternaria solani,[3][4] Phytophthora infestans,[3][4] and Septoria nodorum.[3][4]
Molecular interaction
Famoxadone is of lesser interaction strength at the Qp pocket than some other QoIs, for example, azoxystrobin. This is because azoxystrobin and such interact more centrally in the Qp pocket than does famoxadone.[6]
Resistance management
Although it has a different chemistry, famoxadone shows full cross-resistance with the rest of the main FRAC group 11[4] that it belongs to, which is almost entirely strobs. It has not shown cross-resistance with the 11A subgroup however. As with all QoIs there is a high risk of resistance development and so pesticide stewardship is important.[5][4]
Populations of P. infestans and A. solani in northern and western Europe are not known to be resistant to famoxadone.[4]
External links
- Famoxadone in the Pesticide Properties DataBase (PPDB)
References
- ↑ 1.0 1.1 Famoxadone Pesticide Fact Sheet, United States Environmental Protection Agency
- ↑ Phillip Brannen. "Fungicide resistance management for powdery and downy mildews". http://site.extension.uga.edu/viticulture/files/2021/02/Pathology-Downy-Powdery-Mildew-Presentation-2021.pdf.
- ↑ 3.0 3.1 3.2 3.3 3.4 Knight, S. C.; Anthony, V. M.; Brady, A. M.; Greenland, A. J.; Heaney, S. P.; Murray, D. C.; Powell, K. A.; Schulz, M. A. et al. (1997). "Rationale and Perspectives on the Development of Fungicides". Annual Review of Phytopathology (Annual Reviews) 35 (1): 349–372. doi:10.1146/annurev.phyto.35.1.349. ISSN 0066-4286.
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Schepers, Huub T. A. M.; Cooke, Louise R. (2015). "Potato Pathogens in Northern and Western Europe". in Ishii H., Hollomon D.. Fungicide Resistance in Plant Pathogens. Tokyo: Springer Japan. pp. 355–378. ISBN 978-4-431-55641-1.
- ↑ 5.0 5.1 FRAC (Fungicide Resistance Action Committee) (March 2021). "FRAC Code List ©*2021: Fungal control agents sorted by cross resistance pattern and mode of action (including coding for FRAC Groups on product labels)". pp. 1–17. http://www.frac.info/docs/default-source/publications/frac-code-list/frac-code-list-2021--final.pdf.
- ↑ Cramer, William A.; Zhang, Huamin; Yan, Jiusheng; Kurisu, Genji; Smith, Janet L. (2006). "Transmembrane Traffic in the Cytochrome b6f Complex". Annual Review of Biochemistry (Annual Reviews) 75 (1): 769–790. doi:10.1146/annurev.biochem.75.103004.142756. ISSN 0066-4154.
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