Chemistry:Fluorothiazinone
From HandWiki
Fluorothiazinone (CL-55, Ftortiazinon, Фтортиазинон) is an antibiotic drug, first developed in Russia in 2010 and active against various species of Gram-negative bacteria through inhibition of the type III secretion system (T3SS). It has seen limited clinical use in Russia and is in clinical trials which may eventually see it accepted for use more widely.[1][2][3][4][5][6][7][8][9][10]
See also
- List of Russian drugs
- Aurodox
- Triazavirin
References
- ↑ "A small-molecule compound belonging to a class of 2,4-disubstituted 1,3,4-thiadiazine-5-ones suppresses Salmonella infection in vivo". The Journal of Antibiotics 69 (6): 422–427. June 2016. doi:10.1038/ja.2015.131. PMID 26732253.
- ↑ "A small-molecule compound belonging to a class of 2,4-disubstituted 1,3,4-thiadiazine-5-ones inhibits intracellular growth and persistence of Chlamydia trachomatis". Journal of Medical Microbiology 65 (1): 91–98. January 2016. doi:10.1099/jmm.0.000189. PMID 26489840.
- ↑ "Multidrug-resistant gram-negative organisms: a review of recently approved antibiotics and novel pipeline agents". International Journal of Clinical Pharmacy 42 (4): 1016–1025. August 2020. doi:10.1007/s11096-020-01089-y. PMID 32638294.
- ↑ "Fluorothiazinon, a small-molecular inhibitor of T3SS, suppresses salmonella oral infection in mice". The Journal of Antibiotics 74 (4): 244–254. April 2021. doi:10.1038/s41429-020-00396-w. PMID 33479520.
- ↑ "Preventative treatment with Fluorothiazinon suppressed Acinetobacter baumannii-associated septicemia in mice". The Journal of Antibiotics 75 (3): 155–163. March 2022. doi:10.1038/s41429-022-00504-y. PMID 35064243.
- ↑ "What Is New in the Anti-Pseudomonas aeruginosa Clinical Development Pipeline Since the 2017 WHO Alert?". Frontiers in Cellular and Infection Microbiology 12. 2022. doi:10.3389/fcimb.2022.909731. PMID 35880080.
- ↑ "Fluorothiazinon inhibits the virulence factors of uropathogenic Escherichia coli involved in the development of urinary tract infection". The Journal of Antibiotics 76 (5): 279–290. May 2023. doi:10.1038/s41429-023-00602-5. PMID 36922636.
- ↑ "A novel antivirulent compound fluorothiazinone inhibits Klebsiella pneumoniae biofilm in vitro and suppresses model pneumonia". The Journal of Antibiotics 76 (7): 397–405. July 2023. doi:10.1038/s41429-023-00621-2. PMID 37085670.
- ↑ "От пенициллина — к фтортиазинону" (in Russian). "Chemistry and Life" Popular science magazine. 2024. https://hij.ru/read/31227/.
- ↑ "A New "Non-Traditional" Antibacterial Drug Fluorothiazinone-Clinical Research in Patients with Complicated Urinary Tract Infections". Antibiotics (Basel, Switzerland) 13 (6): 476. May 2024. doi:10.3390/antibiotics13060476. PMID 38927143.
 |  |
