Chemistry:Friedelin

From HandWiki

Friedelin is a triterpenoid chemical compound found in Azima tetracantha, Orostachys japonica,[1] and Quercus stenophylla.[2] Friedelin is also found in the roots of the Cannabis plant.[3] It is noted as having antimicrobial properties[4] and has been recovered from the byproducts of corkboard manufacturing.[5] The compound is also a biological precursor of celastrol.[6] It is considered a friedelane-type compound, appearing structurally similar with the addition of a ketone group.[5]

References

  1. ↑ Medicinal Plants In the Republic of Korea. Natural Products research institute (Seoul National University). p. 187. 
  2. ↑ Onishi, Y; Hanaoka, M (1968). "Studies on the chemical components of Quercus stenophylla Makino. I. Isolation of friedelin from the leaves of Quercus stenophylla Makino" (in Japanese). Yakugaku Zasshi 88 (9): 1244–1245. doi:10.1248/yakushi1947.88.9_1244. PMID 5751298. 
  3. ↑ Russo, Ethan B; Marcu, Jahan (2017). "Cannabis Pharmacology: The Usual Suspects and a Few Promising Leads". Cannabinoid Pharmacology. Advances in Pharmacology. 80. pp. 67–134. doi:10.1016/bs.apha.2017.03.004. ISBN 978-0-12-811232-8. 
  4. ↑ Аrbаin, Dаyаr; Saputri, Gita Ayu; Syahputra, Ghalib Syukrilah; Widiyastuti, Yuli; Susanti, Deny; Taher, Muhammad (2021-10-05). "Genus Pterocarpus: A review of ethnopharmacology, phytochemistry, biological activities, and clinical evidence". Journal of Ethnopharmacology 278. doi:10.1016/j.jep.2021.114316. ISSN 0378-8741. https://www.sciencedirect.com/science/article/pii/S0378874121005432. 
  5. ↑ 5.0 5.1 Yaghoobi Anzabi, Mohadese; Cmoch, Piotr; Luboradzki, Roman; Pakulski, Zbigniew (2024-01-01). "Selective transformations of friedelanes isolated from cork smoker wash solids". Steroids 201. doi:10.1016/j.steroids.2023.109333. ISSN 0039-128X. https://www.sciencedirect.com/science/article/pii/S0039128X23001617. 
  6. ↑ Lu, Yun; Luo, Yunfeng; Zhou, Jiawei; Hu, Tianyuan; Tu, Lichan; Tong, Yuru; Su, Ping; Liu, Yuan et al. (2022). "Probing the functions of friedelane‐type triterpene cyclases from four celastrol‐producing plants" (in en). The Plant Journal 109 (3): 555–567. doi:10.1111/tpj.15575. ISSN 0960-7412. https://onlinelibrary.wiley.com/doi/10.1111/tpj.15575. 
  • Sunil, C; Duraipandiyan, V; Ignacimuthu, S; Al-Dhabi, N. A (2013). "Antioxidant, free radical scavenging and liver protective effects of friedelin isolated from Azima tetracantha Lam. Leaves". Food Chemistry 139 (1–4): 860–5. doi:10.1016/j.foodchem.2012.12.041. PMID 23561182. 




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