Chemistry:GW-788,388
From HandWiki
Short description: Synthetic compound
 | |
| Identifiers | |
|---|---|
| |
| CAS Number | |
| PubChem CID | |
| Chemical and physical data | |
| Formula | C25H23N5O2 |
| Molar mass | 425.492 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
GW 788388 is a synthetic compound which acts as a potent and selective inhibitor for TGF beta receptor 1.[1] It has applications in research into various disorders such as liver, kidney and heart disease (especially associated with Chagas disease),[2][3][4][5][6][7] and potential antiviral properties.[8]
See also
References
- ↑ "Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H- pyran-4-yl)benzamide (GW788388): a potent, selective, and orally active transforming growth factor-beta type I receptor inhibitor". Journal of Medicinal Chemistry 49 (7): 2210–2221. April 2006. doi:10.1021/jm0509905. PMID 16570917.
- ↑ "Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease". PLOS Neglected Tropical Diseases 6 (6): e1696. 2012. doi:10.1371/journal.pntd.0001696. PMID 22720109.
- ↑ "The TGFβ1 Receptor Antagonist GW788388 Reduces JNK Activation and Protects Against Acetaminophen Hepatotoxicity in Mice". Toxicological Sciences 170 (2): 549–561. May 2019. doi:10.1093/toxsci/kfz122. PMID 31132129.
- ↑ "Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis". Kidney International 73 (6): 705–715. March 2008. doi:10.1038/sj.ki.5002717. PMID 18075500.
- ↑ "Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction". American Journal of Physiology. Heart and Circulatory Physiology 298 (5): H1415–H1425. May 2010. doi:10.1152/ajpheart.01048.2009. PMID 20154262.
- ↑ "TGF-β inhibitor therapy decreases fibrosis and stimulates cardiac improvement in a pre-clinical study of chronic Chagas' heart disease". PLOS Neglected Tropical Diseases 13 (7): e0007602. July 2019. doi:10.1371/journal.pntd.0007602. PMID 31365537.
- ↑ "Effects of TGF-β1 Receptor Inhibitor GW788388 on the Epithelial to Mesenchymal Transition of Peritoneal Mesothelial Cells". International Journal of Molecular Sciences 22 (9): 4739. April 2021. doi:10.3390/ijms22094739. PMID 33947038.
- ↑ "Suppression of TGF-β/Smad2 signaling by GW788388 enhances DENV-2 clearance in macrophages". Journal of Medical Virology 94 (9): 4359–4368. September 2022. doi:10.1002/jmv.27879. PMID 35596058.
 |  |
