Chemistry:Gardiquimod
From HandWiki
Short description: Chemical compound
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| Formula | C17H23N5O |
| Molar mass | 313.405 g·mol−1 |
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Gardiquimod is an experimental drug which acts selectively at both mouse and human forms of toll-like receptor 7 (TLR7). It functions as an immune response modifier.[1][2] The core structure is 1H-imidazo[4,5-c]quinoline, as found in related drugs such as imiquimod and resiquimod. It is structurally very similar to resiquimod differing only by an oxygen for nitrogen switch.
References
- ↑ "The TLR7 agonists imiquimod and gardiquimod improve DC-based immunotherapy for melanoma in mice". Cellular & Molecular Immunology 7 (5): 381–8. September 2010. doi:10.1038/cmi.2010.30. PMID 20543857.
- ↑ "Gardiquimod: a Toll-like receptor-7 agonist that inhibits HIV type 1 infection of human macrophages and activated T cells". AIDS Research and Human Retroviruses 29 (6): 907–18. June 2013. doi:10.1089/aid.2012.0313. PMID 23316755.
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