Chemistry:Guvacine
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| Preferred IUPAC name
1,2,5,6-Tetrahydropyridine-3-carboxylic acid | |
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| Properties | |
| C6H9NO2 | |
| Molar mass | 127.143 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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Tracking categories (test):
Guvacine is an hydrogenated pyridine alkaloid found in areca nuts.[1] It is the N-demethylated derivative of arecaidine and the product of ester hydrolysis of guvacoline, both of which are also found in areca nuts as well. It is also an inhibitor of gamma-aminobutyric acid uptake. Lime is said to hydrolyse guvacoline to guvacine.[2]
References
- ↑ Voigt, V; Laug, L; Zebisch, K; Thondorf, I; Markwardt, F; Brandsch, M (2013). "Transport of the areca nut alkaloid arecaidine by the human proton-coupled amino acid transporter 1 (hPAT1)". The Journal of Pharmacy and Pharmacology 65 (4): 582–90. doi:10.1111/jphp.12006. PMID 23488788.
- ↑ Johnston, G. A. R.; Krogsgaard-Larsen, P.; Stephanson, A. (1975). "Betel nut constituents as inhibitors of γ-aminobutyric acid uptake". Nature 258 (5536): 627–628. doi:10.1038/258627a0. ISSN 0028-0836. PMID 1207742. Bibcode: 1975Natur.258..627J. https://ui.adsabs.harvard.edu/abs/1975Natur.258..627J/abstract.
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