Chemistry:HW201877
From HandWiki
HW201877 is a drug which acts as a potent inhibitor of the enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH). It increases levels of prostaglandin E2 and stimulates tissue regeneration, and has been researched in animal studies for treatment of conditions such as inflammatory bowel disease and idiopathic pulmonary fibrosis.[1]
References
- ↑ "Discovery of HW201877: A Highly Potent and Orally Bioavailable Inhibitor of 15-Prostaglandin Dehydrogenase to Potentiate Tissue Repair and Regeneration". Journal of Medicinal Chemistry 68 (13): 14099–14113. July 2025. doi:10.1021/acs.jmedchem.5c01361. PMID 40568827.
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