Chemistry:Hexapeptide-12
Hexapeptide-12 (Elastin hexapeptide) is a hexapeptide with the sequence VGVAPG, which is derived from a sequence found in the connective tissue protein elastin. At low concentrations it can stimulate biosynthesis of elastin and also inhibits production of the inflammatory signalling protein interleukin-6, which gives it an additional antiinflammatory effect.[1][2] However, at higher concentrations VGVAPG upregulates Sirtuin 2 expression which has a pro-aging and neurodegenerative effect, and progressive build-up of VGVAPG levels from degradation of elastin is thought to be an important contributor to the aging process,[3] so VGVAPG is mainly used in research applications into the pro-aging effects of some matrikine peptides, rather than being used as an ingredient in skincare products as with other related compounds.[4][5][6][7]
See also
- Glycyl-prolyl-hydroxyproline
- Hexapeptide-10
- Tetrapeptide-21
References
- ↑ "Modulation by elastin peptide VGVAPG of cell proliferation and elastin expression in human skin fibroblasts". Archives of Dermatological Research 289 (8): 489–492. July 1997. doi:10.1007/s004030050227. PMID 9266029.
- ↑ "Interaction between the elastin peptide VGVAPG and human elastin binding protein". The Journal of Biological Chemistry 288 (2): 1317–1328. January 2013. doi:10.1074/jbc.M112.419929. PMID 23166321.
- ↑ "Elastin-Derived Peptides in the Central Nervous System: Friend or Foe". Cellular and Molecular Neurobiology 42 (8): 2473–2487. November 2022. doi:10.1007/s10571-021-01140-0. PMID 34374904.
- ↑ "Interaction Between Aging-Related Elastin-Derived Peptide (VGVAPG) and Sirtuin 2 and its Impact on Functions of Human Neuron Cells in an In Vitro Model". Molecular Neurobiology 62 (1): 819–831. January 2025. doi:10.1007/s12035-024-04298-y. PMID 38914873.
- ↑ "Proteostasis and autophagy disruption by the aging-related VGVAPG hexapeptide - preliminary insights into a potential novel elastin-induced neurodegeneration pathway in an in vitro human cellular neuron model". Neurochemistry International 187. July 2025. doi:10.1016/j.neuint.2025.105992. PMID 40348194.
- ↑ "Elastin-derived extracellular matrix fragments drive aging through innate immune activation". Nature Aging 5 (12): 2380–2398. December 2025. doi:10.1038/s43587-025-00961-8. PMID 41023316.
- ↑ "Multi-kinase-mediated alterations in Tau phosphorylation, synaptic proteins, and choline metabolism in a human neuronal in vitro model exposed to the elastin-derived hexapeptide VGVAPG". Neuropharmacology 284. February 2026. doi:10.1016/j.neuropharm.2025.110781. PMID 41297585.
 |  |
