Chemistry:IGEPAL CA-630
IGEPAL CA-630 is a nonionic, non-denaturing detergent. Its official IUPAC name is octylphenoxypolyethoxyethanol. IGEPAL is a registered trademark of Rhodia.
IGEPAL CA-630 is sold by Sigma-Aldrich and is claimed to be a "chemically indistinguishable" substitute for Nonidet P-40 (a trademark of Shell Chemical Company) which is no longer manufactured. However, a 2017 publication reported that IGEPAL 630 was ten-fold more potent than Nonidet P-40 in a tubulin polymerisation assay.[1]
All IGEPAL CA surfactants are derived from octylphenol. This serves as the hydrophobic part. Different amounts of ethylene oxide are combined with this part to get a balance of hydrophobic/hydrophilic substances (measured by HLB). This balance has an important impact on wetting detergency, foam, solubility, emulsification. IGEPAL CA-630 has HLB of 13.4, similar to that of Triton X-100 (13.4) and thus belongs to the detergent range (HLB 13-15); this is significantly less than 17.8 of tergitol NP-40 or 16.7 of Polysorbate 20 (also known as Tween 20), which both belong in the solubilizer range (15-18) of HLB.[2]
Ca-630 is completely miscible with water.
Human Toxicity
CA-630 is not a primary skin irritant nor sensitizer.[3] However, it is a severe eye irritant.[4]
See also
References
- ↑ Sinha, S.; Field, J.J.; Miller, J.H. (2017). "Use of substitute Nonidet P-40 nonionic detergents in intracellular tubulin polymerization assays for screening of microtubule targeting agents". Biochemistry and Cell Biology 95 (3): 379–384. doi:10.1139/bcb-2016-0141. PMID 28177759.
- ↑ "The Pharmaceutics and Compounding Laboratory". https://pharmlabs.unc.edu/labs/emulsions/hlb.htm.
- ↑ M.Schick:"Non-ionic Surfactants". p. 929, Marcel Dekker, Inc., N.Y. (1967).
- ↑ http://www.mpbio.com/detailed_info.php?family_key=02198596
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