Chemistry:INT-777

From HandWiki

INT-777 is an experimental drug which acts as a potent and selective agonist for the G protein-coupled bile acid receptor (GPBAR1/TGR5). It has antiinflammatory effects and has been researched for various conditions including diabetes and pulmonary arterial hypertension.[1][2][3][4]

References

  1. ↑ "Potential New Approaches to Modifying Intestinal GLP-1 Secretion in Patients with Type 2 Diabetes Mellitus". Clinical Drug Investigation 32 (1): 1–14. 2012. doi:10.2165/11595370-000000000-00000. PMID 27933595. 
  2. ↑ "Beneficial effects of bile acid receptor agonists in pulmonary disease models". Expert Opinion on Investigational Drugs 26 (11): 1215–1228. November 2017. doi:10.1080/13543784.2017.1385760. PMID 28949776. 
  3. ↑ "The Bile Acid Membrane Receptor TGR5 in Cancer: Friend or Foe?". Molecules (Basel, Switzerland) 27 (16): 5292. August 2022. doi:10.3390/molecules27165292. PMID 36014536. 
  4. ↑ "Emerging Roles of Bile Acids and TGR5 in the Central Nervous System: Molecular Functions and Therapeutic Implications". International Journal of Molecular Sciences 25 (17): 9279. August 2024. doi:10.3390/ijms25179279. PMID 39273226. 



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