Chemistry:Icafolin
From HandWiki
Icafolin is a post-emergent chemical herbicide developed by Bayer.[1] Its formula is C
17H
16F
2N
2O
5.[2] The herbicide was introduced in 2022,[3] registered in 2025, and is anticipated to be introduced in 2028 for use in Brazil.[4] It is a tubulin inhibitor that may be applied to soybeans, corn, and cotton among other crops. The chemical is synthesized as a mixture of (2R,4R) and (2S,4S) stereoisomers through a multi-step process.[2]
Icafolin-methyl, a derivative methyl ester of icafolin,[5] is also a tubulin inhibitor and is hydrolyzed to icafolin in plants.[6]
References
- ↑ Young, Cyndi. "Bayer Unveils Icafolin and Conventro: New Herbicide Technologies Target Resistant Weeds and Support Sustainable Farming" (in en-US). https://www.brownfieldagnews.com/news/bayer-unveils-icafolin-and-conventro-new-herbicide-technologies-target-resistant-weeds-and-support-sustainable-farming/.
- ↑ 2.0 2.1 Template:Cite PubChem
- ↑ "Icafolin". University of Hertfordshire. 9 November 2025. https://sitem.herts.ac.uk/aeru/ppdb/en/Reports/2459.htm.
- ↑ "Bayer submits registration applications for novel herbicide in four major markets". July 30, 2025. https://www.bayer.com/media/en-us/bayer-submits-registration-applications-for-novel-herbicide-in-four-major-markets/.
- ↑ "Icafolin". British Crop Production Council. http://www.bcpcpesticidecompendium.org/icafolin.html.
- ↑ Haaf, Klaus-Bernhard; Peters, Olaf; Laber, Bernd; Lange, Gudrun; Gatzweiler, Elmar; Geibel, Sven; Passon, Daniel; Endler, Anne et al. (2025). "The novel herbicide icafolin-methyl is a plant-specific inhibitor of tubulin polymerization". Pest Management Science 81 (5): 2652–2661. doi:10.1002/ps.8415. ISSN 1526-4998. PMID 39297346.
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