Chemistry:Imidazothiazoles

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Short description: Class of chemical compounds comprising a bicyclic heterocycle
The general structure of imidazothiazoles.

Imidazothiazoles are a class of chemical compounds containing a bicyclic heterocycle (a double ring system) consisting of an imidazole ring fused to a thiazole ring.[1] The structure contains three non-carbon or heteroatoms: two nitrogen atoms and one sulfur atom. Imidazothiazole derivatives show a broad spectrum of in vitro, i.e. "in the petri dish", activity such as anticancer,[2][3][4] antipsychotic,[5] antimicrobial,[6] antifungal,[7] and anthelmintic[8] (against cancer, psychosis, microorganisms, fungi and worms, respectively).

References

  1. ↑ Fascio, Mirta L.; Errea, María Inés; D'Accorso, Norma Beatriz (2015-01-27). "Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties" (in en). European Journal of Medicinal Chemistry 90: 666–683. doi:10.1016/j.ejmech.2014.12.012. PMID 25499987. 
  2. ↑ Gürsoy, Elif; Güzeldemirci, Nuray Ulusoy (2007-03-01). "Synthesis and primary cytotoxicity evaluation of new imidazo[2,1-b]thiazole derivatives" (in en). European Journal of Medicinal Chemistry 42 (3): 320–326. doi:10.1016/j.ejmech.2006.10.012. PMID 17145120. 
  3. ↑ Andreani, Aldo; Granaiola, Massimiliano; Leoni, Alberto; Locatelli, Alessandra; Morigi, Rita; Rambaldi, Mirella; Varoli, Lucilla; Lannigan, Deborah et al. (2011-09-01). "Imidazo[2,1-b]thiazole guanylhydrazones as RSK2 inhibitors [1]" (in en). European Journal of Medicinal Chemistry 46 (9): 4311–4323. doi:10.1016/j.ejmech.2011.07.001. PMID 21794960. 
  4. ↑ Park, Jin-Hun; El-Gamal, Mohammed I.; Lee, Yong Sup; Oh, Chang-Hyun (2011-12-01). "New imidazo[2,1-b]thiazole derivatives: Synthesis, in vitro anticancer evaluation, and in silico studies" (in en). European Journal of Medicinal Chemistry 46 (12): 5769–5777. doi:10.1016/j.ejmech.2011.08.024. PMID 22033063. 
  5. ↑ Cole, Derek C.; Stock, Joseph R.; Lennox, William J.; Bernotas, Ronald C.; Ellingboe, John W.; Boikess, Steve; Coupet, Joseph; Smith, Deborah L. et al. (2007-11-01). "Discovery of N1-(6-Chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a Potent, Selective, and Orally Active 5-HT6 Receptor Agonist". Journal of Medicinal Chemistry 50 (23): 5535–5538. doi:10.1021/jm070521y. PMID 17948978. 
  6. ↑ Güzeldemirci, Nuray Ulusoy; Küçükbasmacı, Ömer (2010-01-01). "Synthesis and antimicrobial activity evaluation of new 1,2,4-triazoles and 1,3,4-thiadiazoles bearing imidazo[2,1-b]thiazole moiety" (in en). European Journal of Medicinal Chemistry 45 (1): 63–68. doi:10.1016/j.ejmech.2009.09.024. PMID 19939519. 
  7. ↑ Malik, Jitender K.; Soni, Himesh; Singhai, A.K. (2013-01-01). "Synthesis, characterization and evaluation for antifungal activity of substituted diaryl imidazo [2, 1, b]-benzothiazole" (in en). Journal of Pharmacy Research 7 (1): 39–46. doi:10.1016/j.jopr.2013.01.002. 
  8. ↑ Amarouch, Hamid; Loiseau, Philippe R; Bacha, Catarina; Caujolle, Raymond; Payard, Marc; Loiseau, Philippe M; Bories, Christian; Gayral, Philippe (1987-09-01). "Imidazo[2,1-b]thiazoles: analogues du lévamisole" (in fr). European Journal of Medicinal Chemistry 22 (5): 463–466. doi:10.1016/0223-5234(87)90037-7. 




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