Chemistry:JYQ-42
From HandWiki
JYQ-42 is a drug which acts as a sirtuin-6 (SIRT6) inhibitor. It has potential applications in cancer treatment, having been found to inhibit the migration of pancreatic cancer cells and thereby reduce tumor invasiveness.[1][2]
References
- ↑ "Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migration of pancreatic cancer cells". Acta Pharmaceutica Sinica B 12 (2): 876–889. 2022. doi:10.1016/j.apsb.2021.06.015. PMID 35256952.
- ↑ "Sirtuins as Key Regulators in Pancreatic Cancer: Insights into Signaling Mechanisms and Therapeutic Implications". Cancers 16 (23): 4095. 2024. doi:10.3390/cancers16234095. PMID 39682281.
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