Chemistry:Ledasorexton

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Ledasorexton (INN; developmental code name E-2086) is a selective orexin OX₂ receptor agonist which is under development for the treatment of narcolepsy.^[1]^[2] It is taken orally.^[1] The drug is under development by Eisai.^[1]^[2] As of May 2026, it is in phase 2 clinical trials for narcolepsy.^[1]^[2]

See also

List of investigational narcolepsy and hypersomnia drugs

References

↑ ^1.0 ^1.1 ^1.2 ^1.3 "Ledasorexton". 27 May 2026. https://adisinsight.springer.com/drugs/800072674.
↑ ^2.0 ^2.1 ^2.2 "Delving into the Latest Updates on Ledasorexton with Synapse". 23 May 2026. https://synapse.patsnap.com/drug/cc4048d75df347f9b61f1c8ab6d0ce3d.

Template:Wakefulness-promoting agents

Signaling peptide/protein receptor modulators

AdipoR₁	Agonists: Peptide: Adiponectin ADP-355 ADP-399; Non-peptide: AdipoRon (–)-Arctigenin Arctiin Gramine Matairesinol Antagonists: Peptide: ADP-400
AdipoR₂	Agonists: Peptide: Adiponectin ADP-355 ADP-399; Non-peptide: AdipoRon Deoxyschizandrin Parthenolide Syringing Taxifoliol Antagonists: Peptide: ADP-400

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Agonists: Bradykinin
Kallidin

Antagonists: FR-173657
Icatibant
LF22-0542

Agonists: Amylin
CGRP
Pramlintide

Cholecystokinin

CCK_A	Agonists: Cholecystokinin Antagonists: Amiglumide Asperlicin Devazepide Dexloxiglumide Lintitript Lorglumide Loxiglumide Pranazepide Proglumide Tarazepide Tomoglumide
CCK_B	Agonists: Cholecystokinin CCK-4 Gastrin Pentagastrin (CCK-5) Antagonists: Ceclazepide CI-988 (PD-134308) Itriglumide L-365,360 Netazepide Proglumide Spiroglumide
Unsorted	Antagonists: Nastorazepide

CRF₁	Agonists: Cortagine Corticorelin Corticotropin releasing hormone Sauvagine Stressin I Urocortin Antagonists: Antalarmin Astressin-B CP-154,526 Emicerfont Hypericin LWH-234 NBI-27914 NBI-74788 Pexacerfont R-121919 TS-041 Verucerfont
CRF₂	Agonists: Corticorelin Corticotropin releasing hormone Sauvagine Urocortin Antagonists: Astressin-B

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GAL₁	Agonists: Galanin Galanin (1-15) Galanin-like peptide Galmic Galnon NAX 810-2 Antagonists: C7 Dithiepine-1,1,4,4-tetroxide Galantide (M15) M32 M35 M40 SCH-202596
GAL₂	Agonists: Galanin Galanin (1-15) Galanin (2-11) Galanin-like peptide Galmic Galnon J18 NAX 810-2 Antagonists: C7 Galantide (M15) M32 M35 M40 M871
GAL₃	Agonists: Galanin Galanin (1-15) Galmic Galnon Antagonists: C7 Galantide (M15) GalR3ant HT-2157 M32 M35 M40 SNAP-37889 SNAP-398299

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GLP-1	Agonists: Albiglutide Beinaglutide Dulaglutide Efpeglenatide Exenatide GLP-1 Langlenatide Liraglutide Lixisenatide Oxyntomodulin Pegapamodutide Semaglutide Taspoglutide
GLP-2	Agonists: Apraglutide Elsiglutide Glepaglutide GLP-2 Teduglutide
Others	Propeptides: Preproglucagon Proglucagon

Propeptides: Preproglucagon
Proglucagon

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Antagonists: BMS-754807
S661
S961

Kinase inhibitors: Linsitinib

Antibodies: Xentuzumab (against IGF-1 and IGF-2)

Agonists: Kisspeptin
Kisspeptin-10

Antagonists: Kisspeptin-234

Agonists: Leptin
Metreleptin

MCH₁	Agonists: Melanin concentrating hormone Antagonists: ATC-0065 ATC-0175 GW-803430 NGD-4715 SNAP-7941 SNAP-94847
MCH₂	Agonists: Melanin concentrating hormone

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Neuropeptide FF

Antagonists: BIBP-3226
RF9

Agonists: Neuropeptide S

Antagonists: ML-154
SHA-68

Y₁	Agonists: Neuropeptide Y Peptide YY Antagonists: BIBO-3304 BIBP-3226 BVD-10 GR-231118 PD-160170
Y₂	Agonists: 2-Thiouridine 5'-triphosphate Neuropeptide Y Neuropeptide Y (13-36) Peptide YY Peptide YY (3-36) Antagonists: BIIE-0246 JNJ-5207787 SF-11
Y₄	Agonists: GR-231118 Neuropeptide Y Pancreatic polypeptide Peptide YY Antagonists: UR-AK49
Y₅	Agonists: BWX-46 Neuropeptide Y Peptide YY Antagonists: CGP-71683 FMS-586 L-152,804 Lu AA-33810 MK-0557 NTNCB Velneperit (S-2367)

NTS₁	Agonists: Neurotensin Neuromedin N Antagonists: Meclinertant SR-142948
NTS₂	Agonists: Neurotensin Antagonists: Levocabastine SR-142948

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OX₁	Agonists: Orexin (A, B) Antagonists: ACT-335827 ACT-462206 Almorexant Filorexant Lemborexant Nemorexant RTIOX-276 SB-334867 SB-408124 SB-649868 Suvorexant TCS-1102
OX₂	Agonists: Orexin (A, B) SB-668875 Antagonists: ACT-335827 ACT-462206 Almorexant EMPA Filorexant JNJ-10397049 Lemborexant MK-1064 SB-649868 Seltorexant Suvorexant TCS-1102 TCS-OX2-29

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Agonists: Growth hormone
Human placental lactogen
Placental growth hormone (growth hormone variant)
Prolactin
S179D-hPRL
Somatotropin

Prolactin modulators: Prolactin inhibitors: D₂ receptor agonists (e.g., bromocriptine, cabergoline); Prolactin releasers: D₂ receptor antagonists (e.g., domperidone, metoclopramide, risperidone)
Estrogens (e.g., estradiol)
Progestogens (e.g., progesterone)

Agonists: Abaloparatide
Parathyroid hormone
Parathyroid hormone-related protein (PTHrP)
Semparatide
Teriparatide

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Agonists: Thyrotropin alfa
TSH (thyrotropin)

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VIPR₁	Agonists: Peptide: Bay 55-9837 LBT-3393 PACAP VIP
VIPR₂	Agonists: Peptide: LBT-3627 PACAP VIP
PAC₁	Agonists: PACAP PACAP (1-27) PACAP (1-38) Antagonists: PACAP (6-38)
Unsorted	PHI PHM PHV

Others

Exogenous: Lifitegrast (LFA-1 antagonist)

See also: Receptor/signaling modulators

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