Chemistry:Lennoxamine
From HandWiki
Lennoxamine is an isoindolobenzazepine alkaloid, originally isolated from the Chilean barberry, Berberis darwinii. Lennoxamine has been synthesised from 6-bromopiperonal in 9 steps;[1]; from 3-(3,4-methylenedioxybenzylidene)-6,7-dimsthoxyphthalide in 4 or 5 steps;[2] and from 2,3-dimethoxybenzoic acid in 8 steps.[3]
References
- ↑ Moody, Christopher J.; Warrellow, Graham J. (January 1987). "Synthesis of the isoindolobenzazepine alkaloid lennoxamine". Tetrahedron Letters 28 (48): 6089–6092. doi:10.1016/s0040-4039(00)96871-0.
- ↑ Napolitano, Elio; Spinelli, Guido; Fiaschi, Rita; Marsili, Antonio (1986). "A simple total synthesis of the isoindolobenzazepine alkaloids lennoxamine and chilenamine". Journal of the Chemical Society, Perkin Transactions 1: 785. doi:10.1039/p19860000785.
- ↑ Couty, Sylvain; Meyer, Christophe; Cossy, Janine (January 2006). "A short synthesis of lennoxamine via ynamides". Tetrahedron Letters 47 (5): 767–769. doi:10.1016/j.tetlet.2005.11.093.
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